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Updated: Jun 23, 2025

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在人类细胞中,SNM1A对复杂DNA断裂的有效修复至关重要

Lonnie P Swift1, B Christoffer Lagerholm2,3, Lucy R Henderson1

  • 1Department of Oncology, MRC-Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

Nature communications
|June 25, 2024
PubMed
概括

金属β-乳糖酶折叠5'3'外核酶SNM1A对于DNA双链断裂 (DSB) 修复至关重要. SNM1A可以从DNA断裂端子中去除氧化修饰,增强细胞对辐射和放射仿真药物的抵抗力.

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