甲诺基甲诺雷登斯古生物群是多样化和相互作用的染色体外元素的宿主
Ling-Dong Shi1, Jacob West-Roberts2, Marie C Schoelmerich1,3
1Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.
Nature microbiology
|June 25, 2024
概括
研究人员在甲氧化古生物 (Methanoperedens) 中发现了新的遗传元素,迷你Borg和病毒. 这些元素可能会影响古生物.
科学领域:
- 微生物学 微生物学
- 遗传学 是一个遗传学.
- 环境科学 环境科学
背景情况:
- 厌氧甲氧化古生物,如甲经,在减轻甲排放方面发挥着至关重要的作用.
- 众所周知,外染色体遗传元素 (ECE),包括大型博格,存在于Methanoperedens中,可能会影响它们的活性.
- 除了博格之外,甲操作的ECE的多样性和影响仍然在很大程度上未被探索.
研究的目的:
- 为了研究在甲运行中的染色体外遗传元素 (ECE) 的多样性.
- 描述新发现的ECE,包括线性元素,病毒和圆形元素.
- 了解这些ECEs对它们的古老宿主的潜在相互作用和进化影响.
主要方法:
- 来自Methanoperedens.com的基因组数据的生物信息分析.
- 新型线性ECE,循环病毒和其他未分类的ECE的识别和表征.
- 基因特征的比较分析,包括共享的蛋白质和编码模式,与已知的Borgs和Methanoperedens.
主要成果:
- 发现了小型线性ECEs,称为迷你Borgs (52145 kb),与Borgs共享特征,但尺寸不同.
- 识别了八个Methanoperedens病毒家族,其中一些编码多血红细胞染色体.
- 用转子子相关基因和CRISPR数组对圆形ECE的表征,表明基因交换.
结论:
- 迷你Borgs代表了一个新的类别的ECEs在Methanoperedens,遗传多样性和潜在的影响宿主活动.
- 已识别的病毒和循环ECE有助于Methanoperedens.com内部复杂的遗传景观.
- 证据表明,这些ECE和它们的Methanoperedens宿主之间有显著的遗传信息交换,影响了古人类的进化.
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