通过食时间准肠道昼夜时钟,可以改善胃肠道炎症
Yunhui Niu1,2, Marjolein Heddes1,2, Baraa Altaha1,2
1ZIEL - Institute for Food & Health, Technical University of Munich, 85354, Freising, Germany.
Cellular & molecular immunology
|June 25, 2024
概括
被破坏的肠钟会使小鼠的炎症性肠病 (IBD) 恶化. 定时食恢复了时钟功能,改善了IBD的结果,这表明时钟增强是IBD患者的潜在治疗方法.
科学领域:
- 胃肠病学 胃肠病学
- 时间生物学 时间生物学
- 免疫学 免疫学 免疫学
背景情况:
- 循环节律障碍与胃肠道疾病风险增加有关,包括炎症性肠道疾病 (IBD).
- 肠上皮细胞 (IEC) 的昼夜时钟调节肠道平衡和微生物群.
- 在IBD患者活检中,时钟基因表达受损.
研究的目的:
- 调查肠道时钟在IBD病变发生过程中的作用.
- 为了确定是否针对肠道时钟可以改善IBD症状.
主要方法:
- 使用IL-10淘汰 (IL-10-/-) 和Bmal1条件淘汰 (Bmal1IEC-/-) 的IBD小鼠模型.
- 使用硫酸德克斯 (DSS) 和遗传模型 (DSS,Bmal1IEC-/-xIL-10-/-) 诱导大肠炎.
- 给定时间的限制性养 (RF) 调节昼夜节律.
主要成果:
- 肠道时钟的干扰促进了结肠炎,并减少了小鼠模型中的存活率.
- 在IEC中,肠钟基因Bmal1的丧失加剧了IBD.
- 限制食恢复了肠道时钟功能,改善了免疫反应,并提高了IL-10-/-小鼠的存活率.
- 在Bmal1IEC-/-xIL-10-/-小鼠中,限制食是无效的,这凸显了功能性肠道时钟的必要性.
结论:
- 肠道时钟功能障碍促进免疫失衡,并推动IBD的发展.
- 通过限制饮食来增强肠道时钟功能是IBD的一个有希望的治疗策略.
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