相关实验视频

Updated: Jun 23, 2025

Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay
07:05

Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay

Published on: September 27, 2024

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通过单个子单位二维基因酶USP16进行核细胞H2AK119二维基因化的结构和机制基础USP16

Huasong Ai1,2, Zaozhen He1, Zhiheng Deng1

  • 1New Cornerstone Science Laboratory, Tsinghua-Peking Joint Center for Life Sciences, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Center for Synthetic and Systems Biology, Department of Chemistry, Tsinghua University, Beijing, China.

Nature structural & molecular biology
|June 25, 2024
PubMed
概括

这项研究揭示了USP16如何从基因素H2AK119中去除乌比奎,这是一个关键的表观遗传标记. 这种deubiquitination机制与其他酶不同,为基因调节和疾病突变提供了洞察力.

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