在乳头甲状腺癌中淋巴结转移,对BRAF V600E和TERT促进器突变的研究
Alif Rizky Soeratman1,2, Diani Kartini1,2, Bob Andinata2,3
1Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Asian Pacific journal of cancer prevention : APJCP
|June 25, 2024
概括
BRAF V600E突变与状甲状腺癌 (PTC) 的部淋巴结转移有关. 单独的TERT突变不会增加风险,但与BRAF突变相结合,它们会显著提高PTC患者的转移风险.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 乳头甲状腺癌 (PTC) 是最常见的甲状腺恶性瘤.
- 部淋巴结 (LN) 转移是PTC的关键预后因素.
- 识别与转移相关的遗传标记可以改善患者管理.
研究的目的:
- 调查BRAF V600E和TERT促进子突变之间的关联以及PTC患者部淋巴结转移的发生率.
- 确定这些突变在预测转移中的独立和联合作用.
主要方法:
- 在Cipto Mangunkusumo医院对42名PTC患者进行的横截面研究.
- 从医疗记录收集回顾性数据,使用BRAF V600E和TERT促进物突变分析.
- 使用PCR主混合进行的BRAF和TERT基因倍增.
- 统计分析包括单变量和双变量分析以及奇方位测试.
主要成果:
- BRAF V600E突变与LN转移有显著的相关性 (p<0.001,OR = 25.33).
- 单独的TERT促进子突变与LN转移无关.
- 与BRAF+/TERT-突变患者相比,与BRAF-/TERT-突变患者相比,LN转移的风险增加了18倍.
- BRAF和TERT突变的组合将LN转移的风险增加了60倍.
结论:
- 在PTC中,BRAF V600E突变是部淋巴结转移的重要预测因素.
- TERT促进子突变不能独立预测转移,但当与BRAF突变同时发生时,会增加风险.
- 这些发现强调了BRAF突变状态及其与TERT突变的相互作用在评估PTC转移潜力的重要性.
更多相关视频
06:09Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
8.7K
08:18Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
Published on: September 8, 2021
2.9K
相关概念视频
Mitogens and the Cell Cycle
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
