肥胖现象与非酒精性脂肪肝之间的关联:一项基于人口的大型研究
Farid Najafi1, Yahya Pasdar1, Mehdi Moradi Nazar1
1Research Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
BMC endocrine disorders
|June 25, 2024
概括
代谢性肥胖表型显著增加非酒精性脂肪肝疾病 (NAFLD) 的风险. 即使是代谢健康的肥胖个体也面临着较高的NAFLD风险,与健康的,非肥胖的同行相比.
科学领域:
- 代谢健康 代谢健康
- 肝脏疾病研究 肝脏疾病研究
- 肥胖的表型化 肥胖的表型化
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的健康问题.
- 了解肥胖和NAFLD之间的联系对于公共卫生至关重要.
- 代谢健康状况显著影响疾病风险.
研究的目的:
- 调查不同代谢性肥胖表型与NAFLD之间的关联.
- 为了确定特定的肥胖模式,提高NAFLD风险.
主要方法:
- 从RaNCD队列研究中对8,360名成年人的横截面分析.
- 基于脂肪肝指数 (FLI) 分数 (≥60) 的NAFLD诊断.
- 分类为四种表型:代谢健康/不健康和肥胖/不肥胖.
主要成果:
- 根据FLI,NAFLD的患病率为39.56%.
- 代谢不健康的个体表现出较低的体力活动.
- 与代谢健康的非肥胖个体相比,在代谢不健康和/或肥胖的表型中观察到NAFLD风险的显著增加,代谢不健康的肥胖表型具有最高风险.
结论:
- 代谢性肥胖现象类型与NAFLD风险增加密切相关.
- 具有新陈代谢健康-肥胖,新陈代谢不健康-非肥胖和新陈代谢不健康-肥胖表型的个体患NAFLD的可能性更高.
- 针对代谢健康和肥胖管理对于NAFLD预防至关重要.
相关概念视频
Obesity
451
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
451
Overview of Lipid Metabolism
1.4K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.4K
Genome-wide Association Studies-GWAS
13.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.3K
Ultrasound II: Endoscopic Ultrasound and FibroScan
96
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
96


