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晚期肺癌炎症指数与腹腔透析患者的死亡率有关

Zhouhao Ren¹, Jiaying Wu², Shaorui Wu³

¹Department of Nephrology, Shaoxing People's Hospital, Shaoxing, 312000, China.

|June 25, 2024

概括

较低的晚期肺癌炎症指数 (ALI) 与腹腔透析 (PD) 患者的死亡率增加有关. 这个指数显示出作为预测患者结果和生存率的有效工具的希望.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
炎症标志物的炎症标志物
预测指标预测指标

背景情况:

腹腔透析 (PD) 与高发病率和死亡率有关.
系统性慢性低度炎症是PD患者的一个关键特征.
晚期肺癌炎症指数 (ALI) 与癌症预后有关.

研究的目的:

调查ALI与PD患者死亡率之间的关系.
确定ALI是否可以预测全因和心血管疾病 (CVD) 死亡率.
与其他生物标志物相比,评估ALI的预测价值.

主要方法:

招募了277名PD患者,并对死亡结果进行了随访.
根据ALI的中位数,患者被分为高ALI和低ALI组.
卡普兰-梅尔曲线,考克斯回归和ROC曲线用于分析.

主要成果:

在低ALI组中观察到较低的累积和心血管生存率.
较低的ALI是所有原因和心血管疾病死亡率增加的独立风险因素 (HR分别> 1.9和2.6).
与专蛋白,BMI和中性粒细胞与淋巴细胞比率相比,ALI显示出所有原因死亡率的优异预测值.

结论:

较低的晚期肺癌炎症指数 (ALI) 是PD患者死亡的独立风险因素.
ALI显示出作为PD患者有效预后指标的潜力.
进一步的研究可能会验证ALI在PD管理中常规临床使用.

关键词:

晚期肺癌的炎症指数是什么所有原因的死亡率.心血管死亡率的心血管死亡率腹膜透析是指腹膜透析.

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