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德国COVID-19期间和之后的HIV PrEP使用和覆盖率的动态在德国COVID-19期间和之后的动态

Daniel Schmidt¹, Yannick Duport², Christian Kollan³

¹Department of Infectious Disease Epidemiology, Robert-Koch Institute, Berlin, Germany. SchmidtD@rki.de.

BMC public health

|June 25, 2024

概括

暴露前预防 (PrEP) 显著有助于预防艾滋病毒. 一个新的模型跟踪了德国的PrEP使用情况,揭示了COVID-19的缓慢吸收,并突出了城市和农村地区之间的差异.

科学领域:

公共卫生公共卫生
流行病学流行病学
数学建模的数学建模

背景情况:

使用口服emtricitabine/tenofovir disoproxil (FTC/TDF) 的暴露前预防 (PrEP) 对预防艾滋病毒非常有效.
自2019年9月以来,FTC/TDF-PrEP被德国医疗保险所覆盖,用于获得许可的专家的处方.
目前在德国缺乏用于纵向监测PrEP实施的方法.

研究的目的:

利用匿名处方数据,开发一种用于监测和预测德国PrEP实施的方法.
量化COVID-19大流行对PrEP吸收的影响.
评估国家和地区的PrEP覆盖率,并确定差异.

主要方法:

开发一个数学模型,利用匿名的FTC/TDF处方数据从2017-2021年.
将艾滋病毒治疗与PrEP处方脱而出,以估计PrEP使用者的数量.
分析过去和未来的PrEP吸收动态,PrEP需要覆盖,以及COVID-19的影响.

主要成果:

确定了2020年4月和12月COVID-19封锁对PrEP吸收的显著减缓影响.
据估计,到2021年12月,PrEP用户达到26,159人,达到33%的需要者覆盖率.
预测显示,到2030年12月将有64,794名PrEP使用者 (81%的覆盖率),其中有显著的区域差异有利于大都市地区.

结论:

开发的方法为使用匿名数据监测和预测PrEP实施提供了一个全面的解决方案.
随着COVID-19大流行,德国的PrEP采用率大幅下降.
农村地区PrEP吸收率较低表明在护理,教育或信息获取方面存在结构性障碍,可能阻碍了2030年艾滋病流行目标.

关键词:

在 COVID-19 疫情中,德国德国德国德国艾滋病毒PrEP使用者药品处方数据药品处方数据关于PrEP的覆盖范围需要PREP需要PREP

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