Mycobacterium结核病治疗对瘤造影评估血静的作用:一个前性队列研究
Hans Johan Niklas Lorentsson1,2,3,4, Christina R Clausen5,6,7, Daniel Faurholt-Jepsen8,9
1Section of Infectious Diseases, Department of Medicine, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark. hans.johan.niklas.lorentsson.02@regionh.dk.
Thrombosis journal
|June 25, 2024
概括
结核感染 (TBI) 和结核病 (TB) 的治疗降低了最大凝块强度 (MA). 这一发现表明结核病治疗对心血管有潜在的益处,影响血液静止.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 心血管医学 心血管医学
背景情况:
- 结核病 (TB) 和结核感染 (TBI) 与心血管疾病风险增加有关,可能是由于感染相关的静血变化.
- 结核菌治疗对血液静止的作用仍然在很大程度上是未知的.
研究的目的:
- 调查结核病或TBI的治疗是否会影响血液静止.
- 为了评估结核病/TBI治疗后的血静学参数的变化.
主要方法:
- 一组结核病或TBI患者从结核病门诊处招募.
- 排除标准包括使用抗血栓药物或全身免疫抑制剂.
- 在治疗前和治疗后进行了TEG分析,以测量凝块开始 (R),速度 (K),积累 (角度),最大强度 (MA) 和纤维解析 (LY30).
主要成果:
- 这项研究包括11名结核病患者和15名TBI患者.
- 对结核病和TBI的治疗显著降低了最大凝块强度 (MA) (p=0.016对于结核病,p=0.023对于TBI).
- 治疗后没有观察到R,K,角度或LY30参数的显著变化.
结论:
- 结核病和TBI治疗与MA的减少有关.
- 这种MA的减少可能表明结核病疗法所带来的潜在心血管益处.
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