孕产妇的SARS-CoV-2影响胎儿的胎盘巨细胞程序和来自胎盘的神经发育的微质模型
Lydia L Shook1,2, Rebecca E Batorsky3, Rose M De Guzman1,2,4
1Vincent Center for Reproductive Biology, Massachusetts General Hospital, 55 Fruit Street, Thier Research Building, 903B, Boston, MA, 02114, USA.
Journal of neuroinflammation
|June 25, 2024
概括
母亲的SARS-CoV-2感染会影响胎盘的霍夫尔细胞 (Hofbauer cells,简称HBCs),这些细胞可以分化成类似微质细胞. 这些细胞表现出功能受损,这表明研究子宫内神经发育影响的模型.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
背景情况:
- 母亲的SARS-CoV-2感染会触发免疫反应,影响胎儿的大脑发育.
- 胎儿大脑微质细胞对于神经发育至关重要,但很难在子宫内进行研究.
- 霍夫尔细胞 (Hofbauer cells,HBCs) 是胎盘巨细胞,与微质细胞共享转录程序.
研究的目的:
- 调查母体SARS-CoV-2对胎盘霍夫尔细胞 (HBCs) 的影响.
- 评估HBC是否可以作为研究子宫内微质编程和功能的替代模型.
主要方法:
- 分析了使用单细胞RNA测序的SARS-CoV-2阳性和负性的妊娠期胎盘的HBCs.
- 评估与细胞和微质功能相关的基因表达.
- 转分化的HBC转化为类似微质细胞 (HBC-iMGs),以模拟突触修剪.
主要成果:
- SARS-CoV-2 改变了不同的 HBC 亚种群,其中一些表现为受损的细胞化.
- 从SARS-CoV-2阳性怀孕中获得的HBC-iMGs与对照组相比,显示突触修剪受损.
- 证明了HBCs和微质细胞之间的共享细胞程序和功能相似性.
结论:
- 霍夫尔细胞可以用来创建个性化的后代微质编程的细胞模型.
- HBCs提供了一个可行的非侵入性模型来研究母亲感染对胎儿神经发育的影响.
关键词:
在 COVID-19 疫情中,胎儿的大脑 胎儿的大脑霍夫巴乌尔细胞是什么?微质细胞中的微质细胞神经发育 神经发育这是神经免疫性疾病.胎盘 胎盘 胎盘 胎盘这就是SARS-CoV-2病毒.单细胞RNA测序的一个细胞.更多相关视频
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