打破障碍:细菌-微藻共生系统作为益生菌传递系统
Hui Huang1,2, Xiaoyang Liu1,2, Yutong Lang1,3
1Eye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Journal of nanobiotechnology
|June 25, 2024
概括
一种新的细菌-微藻共生系统有效地将益生菌输送到肠道,克服了改善炎症性肠病 (IBD) 治疗的障碍. 这种方法增强了益生菌的殖民和胃肠道疾病的疗效.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 生物技术是生物技术.
背景情况:
- 炎症性肠病 (IBD) 的发病与肠道微生物群失调有关.
- 益生菌为IBD提供了安全的治疗策略,但它们的有效性受到胃肠道屏障的限制.
- 目前的口服益生菌输送方法具有较低的生物利用性和不良的肠道殖民.
研究的目的:
- 开发一种细菌-微藻共生系统,用于针对性地向肠道输送益生菌.
- 为了提高益生菌在治疗大肠炎的治疗效果.
- 克服口服益生菌输送系统的局限性.
主要方法:
- 使用益生菌大肠杆菌Nissle 1917 (EcN) 和微藻Spirulina platensis (SP) 创建了一个共生系统 (EcN-SP).
- 该SP载体被用来保护EcN免受胃肠道障碍,并促进肠道殖民.
- 口服 EcN-SP 的疗效在结肠炎模型中进行了评估.
主要成果:
- 通过EcN-SP系统,EcN增强了EcN的扩散和有效的肠道输送和殖民.
- SP的独特特性最大限度地减少了胃肠道中的益生菌损失,确保了持续的肠道保留.
- 口服EcN-SP显著降低了肠道炎症因素,改善了肠道屏障功能,并重新平衡了肠道微生物群.
结论:
- 细菌-微藻共生系统 (EcN-SP) 提供了一种可行,安全和有效的方法,用于有针对性的益生菌输送.
- 这种创新的输送策略在治疗炎症性肠病和其他胃肠道疾病方面具有重大前景.
- 这项研究强调了自然启发的共生系统在治疗应用中的潜力.
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