揭开隐藏的玩家:非编码RNAs编排疾病中的聚胺代谢
Marianna Nicoletta Rossi1, Cristian Fiorucci1, Paolo Mariottini1
1Department of Sciences, University of Roma Tre, 00146, Rome, Italy.
Cell & bioscience
|June 25, 2024
概括
多氨酸 (PA) 调节细胞功能,但它们的失调与疾病有关. 非编码RNAs (ncRNAs) 对于控制PA水平至关重要,并与各种健康障碍有关.
科学领域:
- 分子生物学分子生物学
- 细胞生理学 细胞生理学
- 生物化学 生物化学
背景情况:
- 聚氨酸 (PA) 是重要的多聚氨酸,参与细胞平衡,增殖和基本过程,如DNA转录和RNA转化.
- 抗氧化素水平的调节失调与炎症,氧化应激,神经退行和癌症进展有关.
- 细胞内PA水平受到吸收,生物合成和代谢的严格调节.
研究的目的:
- 审查非编码RNAs (ncRNAs) 在调节聚胺 (PA) 基因中的作用.
- 为了强调ncRNA介导的PA基因调节在健康疾病中的变化.
- 突出ncRNAs在维持细胞PA平衡中的重要性.
主要方法:
- 文献综述侧重于非编码RNA (ncRNA) 和它们与聚胺 (PA) 代谢酶的相互作用.
- 分析研究研究微RNAs,长非编码RNAs和circRNAs在PA基因调节中的作用.
- 检查ncRNA介导的PA调制发生变化的病理状况.
主要成果:
- 非编码RNAs (ncRNAs),包括microRNAs,lncRNAs和circRNAs,正在成为聚胺 (PA) 代谢酶的关键调节者.
- 在癌症和大脑疾病等病理条件中经常观察到ncRNA表达模式的改变.
- ncRNAs通过调节基因表达和mRNA代谢来微调PA稳态.
结论:
- ncRNAs在复杂的聚胺 (PA) 代谢调节中发挥着关键作用.
- 了解ncRNA-PA基因相互作用,可以深入了解疾病病原和潜在的治疗策略.
- 对PA通路的ncRNA调节的进一步研究对于解决各种健康障碍至关重要.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
01:31Translation
14.8K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
Translation Produces the Building Blocks of Life
Proteins are...
14.8K
02:23RNA Editing
9.0K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.0K
02:31Nuclear Export of mRNA
7.7K
Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
7.7K
01:20Types of RNA
5.7K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
5.7K
02:27Nonsense-mediated mRNA Decay
10.6K
The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
10.6K