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阻塞性睡眠呼吸暂停查和外科手术对宏壮病的影响:一项前性研究

Jaeyoung Cho^1,2, Jung Hee Kim^2,3, Yong Hwy Kim^3,4

¹Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Endocrinology and metabolism (Seoul, Korea)

|June 26, 2024

概括

在STOP-Bang问卷有效选阻塞性睡眠呼吸暂停 (OSA) 在壮症患者. 内镜手术改善了与胰岛素样生长因子1 (IGF-1) 水平降低相关的OSA.

科学领域:

内分泌学在内分泌学.
睡眠医学睡眠医学
神经外科神经外科

背景情况:

巨,一种由生长激素过量引起的疾病,与阻塞性睡眠呼吸暂停 (OSA) 的高患病率有关.
在这个人群中确定有效的OSA查工具对于及时干预至关重要.
评估壮症手术治疗对OSA严重性的影响对于患者管理很重要.

研究的目的:

为了确定一个可靠的查工具阻塞性睡眠呼吸暂停 (OSA) 在患有缩症的患者.
为了评估内透膜透手术在改善OSA在壮病患者的疗效.
探索生化标志物和OSA手术后改善之间的关系.

主要方法:

预期招募成年壮病患者接受内镜式透形外科手术的患者.
呼吸事件指数 (REI) 测量了手术前和后作为呼吸暂停-呼吸暂停指数的替代品.
评估用于OSA查的STOP-Bang问卷和IGF-1水平与REI的相关性.

主要成果:

68.6%的壮症患者患有OSA,42.9%患有中度至重度OSA.
STOP-Bang评分 (≥3) 显示了中度至重度OSA的高灵敏度 (93.3%) 和负预测值 (87.5%).
内镜手术导致OSA严重程度显著降低 (平均REI差异为-9.5 / 小时),改善与IGF-1水平降低相关.

结论:

STOP-Bang问卷是一个经过验证和可靠的查工具,用于在壮病患者中发现OSA.
透视透视手术显著改善了壮症中OSA的严重程度.
手术后的OSA改善与血清IGF-1水平降低有关,突出显示了内分泌链接.

关键词:

壮成长是一种壮成长.内镜透形手术是指内镜透形手术.呼吸道测谎仪的使用方法查检查查检查查检查睡眠呼吸暂停,阻塞性呼吸暂停.

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