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通过FGF途径对SRC蛋白进行解剖植物化合物疗法准 - - 一种综合方法整合Omics数据分析,网络药理学,虚拟查和分子动力学

Pankaj Kumar Tripathi¹, Chakresh Kumar Jain¹

¹Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, NOIDA, Uttar Pradesh, 201309, India.

Recent advances in food, nutrition & agriculture

|June 26, 2024

概括

这项研究确定了SRC作为结直肠癌 (CRC) 发展中的关键基因,并揭示了Rutin,一种天然化合物,作为潜在的SRC抑制剂. 进一步的研究可能会验证鲁作为CRC的新型治疗剂.

科学领域:

基因组学和生物信息学
分子生物学分子生物学
计算化学的计算化学

背景情况:

结肠直肠癌 (CRC) 是一种由遗传突变和环境因素驱动的复杂疾病,需要个性化治疗策略.
识别关键基因和天然治疗化合物对于推进CRC诊断和治疗至关重要.

研究的目的:

为了确定与结直肠癌 (CRC) 相关的预后基因.
探索天然生物活性化合物作为潜在的治疗剂,针对已识别的CRC基因.
阐明SRC基因在CRC进展及其向抑制中的作用.

主要方法:

差异基因表达分析和蛋白质-蛋白质相互作用网络构建以确定关键基因.
功能和路径分析,重点关注CRC中的SRC信号机制.
虚拟选,分子对接和分子动力学模拟,以评估天然化合物作为SRC抑制剂.

主要成果:

在CRC中鉴定了3621个显著的差异表达基因 (DEG),其中SRC被突出显示为关键基因.
RAS-RAF-MEK-ERK和Wnt/β-catenin通路的SRC激活促进CRC细胞的增殖和入侵.
鲁丁对SRC表现出强烈的结合亲和力,在分子模拟中表现优于现有的药物,表明其治疗潜力.

结论:

通过影响关键细胞通路,SRC在结直肠癌 (CRC) 病原发生过程中发挥着至关重要的作用.
鲁成为一个有前途的天然SRC抑制剂,为CRC提供了潜在的新疗法策略.
需要进一步的实验验证,以确认Rutin作为CRC治疗的有效性.

关键词:

结肠直肠癌是一种癌症.个人隐私信息网络分析PPI网络分析文学采矿采矿采矿分子动力学模拟.分子机制的分子机制.治疗药物治疗药物

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