相关实验视频
Updated: Jun 23, 2025

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.6K
针对个性化TSH参考范围:在三个独立的队列中基于遗传和人口的方法
Aleksander Kuś1,2,3, Rosalie B T M Sterenborg1,2,4, Eirin B Haug5
1Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.
概括
使用多基因分数 (PGS) 个性化甲状腺功能障碍诊断可以完善甲状腺刺激激素 (TSH) 参考范围. 这种遗传方法重新分类了许多个体,提高了甲状腺疾病的诊断准确性和治疗决策.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
- 内部医学 内部医学
背景情况:
- 血清甲状腺刺激激素 (TSH) 对于诊断甲状腺功能障碍至关重要.
- 现有的基于人口的TSH参考间隔由于高个体间变化而存在局限性.
- 遗传因素显著影响TSH度.
研究的目的:
- 通过使用多基因分数 (PGS) 制定基因确定TSH参考范围.
- 评估这些个性化范围对诊断重新分类的影响.
- 评估对甲状腺疾病管理和甲状腺素 (LT4) 处方的临床影响.
主要方法:
- 在没有甲状腺疾病的队列中计算了包括59种遗传变异的多基因分数 (PGS).
- 基因确定TSH参考范围与基于人口的范围进行了比较.
- 在独立的队列中分析了对诊断重新分类和LT4处方模式的影响.
主要成果:
- PGS解释了显著更多的TSH变异 (9.211.1%) 比FT4 (2.42.7%).
- 在PGS四分位数中,基因决定的范围在PGS四分位数中变化很大.
- 高达30.1%的个人从亚临床甲状腺功能障碍被重新分类为euthyroid状态.
结论:
- 个体遗传特征可以个性化TSH参考范围,影响诊断和治疗.
- 个性化的范围为更准确的甲状腺疾病管理提供了潜力.
- 需要进一步精制PGS以捕捉更多的TSH变异.
相关概念视频
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
What is Population Genetics?
57.9K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
57.9K
Polygenic Traits
65.7K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
65.7K

