尼古丁胺胺N-甲基转移酶 (NNMT):一种新的代谢综合征治疗点
Wei-Dong Sun1, Xiao-Juan Zhu1, Jing-Jing Li1
1Key Lab of Aquatic Training Monitoring and Intervention of General Administration of Sport of China, Physical Education College, Jiangxi Normal University, Nanchang, China.
Frontiers in pharmacology
|June 26, 2024
概括
尼古丁胺N-甲基转移酶 (NNMT) 通过影响能量代谢和胰岛素抵抗,在代谢综合征 (MetS) 中发挥关键作用. 针对NNMT可能为MetS和相关疾病提供新的治疗策略.
科学领域:
- 生物化学 生物化学
- 代谢研究研究 代谢研究
- 遗传学 遗传学 是一个
背景情况:
- 代谢综合征 (MetS) 的特点是肥胖,高血压,高血糖和高脂血症,这些都源于能量代谢失调.
- 胰岛素耐药性 (IR) 和脂质代谢异常是MetS病变的核心.
- 尼古丁胺N-甲基转移酶 (NNMT) 正成为代谢失调的重要因素.
研究的目的:
- 调查NNMT在代谢综合征 (MetS) 病变发生中的作用.
- 探索NNMT作为MetS和相关疾病的潜在治疗标.
- 了解将NNMT与代谢障碍联系起来的分子机制.
主要方法:
- 在NNMT基因中分析单核酸变异 (SNV).
- 在肝脏和脂肪组织中测量NNMT基因表达.
- 使用RNA干扰 (RNAi) 和小分子抑制剂向NNMT的实验研究.
主要成果:
- NNMT基因变异与肥胖,2型糖尿病 (T2D),高脂血症和高血压有关.
- 在MetS和相关疾病患者的代谢组织中观察到高NNMT表达.
- 降低NNMT可以增加能量消耗,减少脂质积累,改善胰岛素敏感性.
结论:
- NNMT活动会影响NAD+和同类半氨酸水平,使其与MetS病原发生有关.
- 准NNMT显示了预防和治疗MetS相关疾病的治疗潜力.
- 需要进一步的研究,以充分阐明NNMT的机制,并验证临床应用.
相关概念视频
Electron Transport Chain: Complex I and II
12.8K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
12.8K
Drugs Acting on Autonomic Ganglia: Stimulants
1.3K
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
1.3K
Transducer Mechanism: Nuclear Receptors
1.3K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.3K


