相关实验视频
Updated: May 13, 2026

10:23
Using Luciferase to Image Bacterial Infections in Mice
Published on: February 18, 2011
20.4K
火毒素露西布法金在生物发光的起源后演变
Chengqi Zhu1,2,3, Xiaoli Lu1,2,3, Tianlong Cai1
1Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang 310024, China.
PNAS nexus
|June 26, 2024
概括
火生物发光可能没有演变为一种警告信号,用于毒素称为lucibufagins (LBGs). 这些毒素比发光能力晚进化,这表明火虫光的其他来源.
科学领域:
- 进化生物学 进化生物学
- 生物化学 生物化学
- 昆虫学 昆虫学是一门学科.
背景情况:
- 火虫生物发光广泛存在,一个突出的假设表明它的起源是毒性警告信号.
- 这种警告信号假设认为,火虫进化了光的产生,以宣传防御性毒素的存在,如光菌素 (LBGs).
- 纵观火虫物种,LBGs的进化时间表和分布在很大程度上仍然没有特征,这阻碍了对这一假设的测试.
研究的目的:
- 通过测试警告信号假设来调查火虫生物发光的进化起源.
- 为了确定 lucibufagins (LBGs) 在多种火血统的遗传分布.
- 推断LBG获得的进化时间相对于生物发光的进化.
主要方法:
- 在各种火虫物种中,系统地查露西布法金 (LBGs) 的存在或不存在.
- 用基因组数据进行的遗传学分析,以构建一个全面的火虫遗传学.
- 祖先状态的重建,以推断LBG存在的进化历史.
主要成果:
- Lucibufagins (LBGs) 已在Lampyrinae亚科中得到证实,但在其他主要的火虫系中发现不存在 (例如,Luciolinae,Ototretinae,Psilocladinae, Rhagophthalmidae).
- 祖先状态的重建表明,LBGs可能在Lampyrinae亚家族内演化,比所有火虫的共同祖先要晚得多.
- 在含有LBG的物种中,火ATPα (LBGs的目标) 对这些毒素的敏感性降低,这表明耐药性已经进化.
结论:
- 露西布法金 (LBG) 的进化时间表明,火虫生物发光并不是源自这些特定毒素的警告信号.
- 在未来的研究中,应优先考虑火生物发光的进化替代假设.
- 含有毒素的火虫中对LBG的目标部位不敏感性突出了自毒性管理的机制.
相关概念视频
Mutations
Overview
Reporter Genes
Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
Commonly used reporter...
Commonly used reporter...
Mutations
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Energy Transfer in Chemical Reactions
Chemical reactions require sufficient energy to cause the matter to collide with enough precision and force that old chemical bonds can be broken and new ones formed. In general, kinetic energy is the form of energy powering any type of matter in motion. Imagine a person building a brick wall. The energy it takes to lift and place one brick on top of another is the kinetic energy—the energy matter possesses because of its motion. Once the wall is in place, it stores potential energy. Potential...
Origin of Photosynthesis
Photosynthesis represents a fundamental biological process that transformed Earth's atmosphere and paved the way for complex life. Emerging roughly 3.4–3.8 billion years ago, the earliest photosynthetic organisms harnessed light energy to produce organic compounds. These anoxygenic phototrophs used electron donors like hydrogen sulfide (H₂S) or ferrous iron (Fe²⁺), rather than water, and did not release molecular oxygen (O₂) as a byproduct. Various groups, including green sulfur and purple...
Evolution of New Traits in Microbes
Microorganisms evolve rapidly due to their large population sizes and short generation times, often exhibiting measurable changes within days under laboratory conditions. Natural selection acts on standing genetic variation, enabling the retention and amplification of beneficial traits that confer fitness advantages in changing environments.Adaptive Pigment Regulation in RhodobacterIn Rhodobacter, a genus of purple non-sulfur bacteria, light-harvesting pigments such as bacteriochlorophyll and...

