不同甜味剂对口腔微生物群的影响:一项随机临床探索试点研究
Davis R Zakis1,2, Bernd W Brandt1, Suzette V van der Waal1
1Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, The Netherlands.
Journal of oral microbiology
|June 26, 2024
概括
胰岛素显著改变了口腔斑块微生物群,而异醇和三醇则影响了舌头微生物群. 甜味剂以不同的方式调节口腔微生物群,而胰岛素显示出最强的效果.
科学领域:
- 口腔微生物学 口腔微生物学
- 微生物组研究的研究.
- 牙卫生 牙卫生
背景情况:
- 口腔微生物组在保持口腔健康方面发挥着至关重要的作用.
- 了解诸如甜味剂之类的常见成分如何影响口腔微生物群对于产品开发和消费者健康至关重要.
- 以前的研究还没有完全阐明各种甜味剂对口腔微生物群落的具体影响.
研究的目的:
- 为了评估口腔冲洗中五种常见的甜味剂 (葡萄糖,胰岛素,异醇,塔加,三醇) 对口腔微生物群的调节作用.
- 为了比较不同甜味剂对牙斑块和舌头微生物群组成的影响.
- 评估二次结果,例如牙斑光变化和唾液pH值的变化.
主要方法:
- 一个单中心,双盲,并行随机临床试验,涉及65名18-55岁的健康志愿者.
- 参与者在两周内每天冲洗三次,使用10%的甜味剂溶液.
- 使用16S rRNA基因安普利康序列分析了口腔微生物组成;作为二次结果,测量了斑块光和唾液pH值.
主要成果:
- 观察到牙斑微生物群的显著变化与胰岛素和胰岛素.
- 舌头微生物群的组成被异醇和三醇显著改变.
- 胰岛素对斑块微生物群产生了最明显的影响,其中13种物种发生了显著的变化.
结论:
- 甜味剂对口腔微生物群的影响是甜味剂依赖的.
- 在测试的甜味剂中,胰岛素表现出最强的微生物调节潜力.
- 需要进一步的大规模临床研究来证实这些发现并探索临床影响.
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