循环维生素水平与甲状腺疾病的关联:孟德尔的随机化研究
Wenke Zhang1,2, Erhao Liu1,2, Huafa Que1
1Department of Traditional Chinese Surgery, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Frontiers in endocrinology
|June 26, 2024
概括
这项研究使用了门德尔的随机化来研究维生素水平和甲状腺疾病. 研究结果表明,维生素C可以预防自身免疫性甲状腺功能低下症,而维生素A和维生素D水平与其他甲状腺疾病有关.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 遗传学 遗传学 是一个
背景情况:
- 对甲状腺疾病的维生素补充剂的观察性研究产生了相互矛盾的结果.
- 维生素水平和甲状腺疾病之间的因果关系尚不清楚.
- 这项研究解决了对维生素与甲状腺疾病关联的清晰度的需求.
研究的目的:
- 研究循环维生素水平与各种甲状腺疾病之间的双向因果关系.
- 利用遗传数据对这些关联进行可靠的评估.
主要方法:
- 进行了一项双样双向门德尔随机化 (MR) 研究.
- 使用全基因组关联研究 (GWAS) 的维生素A,B9,B12,C,D,E和甲状腺疾病 (自身免疫性甲状腺功能障碍,自身免疫性甲状腺功能障碍,甲状腺结节,甲状腺癌) 的数据.
- 采用了反变量加权 (IVW-RE),加权中位数 (WM) 和MR-Egger方法,并对强度进行了敏感性分析.
主要成果:
- 维生素C是对自身免疫性甲状腺功能低下症 (ORIVW-RE=0.69) 的保护因素.
- 对自身免疫性甲状腺功能障碍的遗传敏感性与较低的维生素A水平有关 (ORIVW-RE=0.97).
- 甲状腺结节与更高的维生素D水平有关 (ORIVW-RE=1.02).
结论:
- 为维生素水平和甲状腺疾病之间的双向因果关系提供遗传证据.
- 这些发现为维生素在预防和治疗甲状腺疾病中的临床应用提供了洞察力.
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