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对遗传性髓性甲状腺癌的关键点进行了批判性评估
Daqi Zhang1, Nan Liang1, Hui Sun1
1Division of Thyroid Surgery, The China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun, China.
Frontiers in endocrinology
|June 26, 2024
概括
骨髓性甲状腺癌 (MTC) 很少见,通过素 (Ctn) 水平和RET基因突变分析来诊断. 早期的手术提供治愈,而晚期的手术可能使用氨酸激酶抑制剂.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 甲状腺髓性癌 (MTC) 占甲状腺癌的3%,其中75%是零星性 (sMTC) 和25%是遗传性 (hMTC),与多发性内分泌新陈代谢2型 (MEN2) 相关.
- 早期诊断MTC对于有效的管理和改善患者结果至关重要.
- 识别RET原基因突变有助于诊断遗传性MTC和管理受影响的家庭.
研究的目的:
- 概述甲状腺髓癌 (MTC) 的诊断标准和治疗策略.
- 强调色素 (Ctn) 水平和RET突变分析在MTC管理中的重要性.
- 确定MTC患者的后续分类和进展监测.
主要方法:
- 确定瘤标志物素 (Ctn) 水平,用于诊断和监测.
- 检测RET原基因突变用于遗传MTC识别.
- 使用pTNM分期,RECIST标准和Ctn翻倍时间来评估瘤进展.
主要成果:
- 素 (Ctn) 水平指导手术干预值 (>100 pg/ml建议进行手术).
- 整体甲状腺切除术与中枢淋巴结除术是早期MTC的主要治疗方法.
- 先进的MTC可以用氨酸激酶抑制剂治疗,在进展的情况下,局部治疗优先于全身治疗.
结论:
- 准确的诊断和MTC的分期对于量身定制的治疗至关重要.
- 术后监测,包括Ctn水平和RET分析,对于患者的随访至关重要.
- 主动监测通常是可行的,治疗决策以瘤进展和患者症状为指导.
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