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慢性肝酶提升和当代ARV在艾滋病毒感染者中使用

Ashley O Roen¹, Lars Peters², Gilles Wandeler³

¹Institute for Global Health, University College London, London, UK.

Open forum infectious diseases

|June 26, 2024

概括

较新的抗逆转录病毒药物 (ARV) 显示出不同的肝酶升高风险. 非核酸逆转录酶抑制剂和诺福维尔二二醇烟酸增加风险,而达鲁纳维尔降低风险,没有观察到累积效应.

科学领域:

肝病学肝病学是一种肝病学.
传染性疾病传染性疾病
药理学药理学是指药理学的学科.

背景情况:

慢性肝酶升高 (cLEE) 是已知的抗逆转录病毒药物 (ARV) 的已知并发症.
较新的ARVs的肝脏安全性,特别是关于cLEE,仍然在很大程度上没有特征.

研究的目的:

调查与各种新型ARV相关的clee发病率.
为了确定ARV暴露时间是否会影响cLEE的风险.
确定与增加或减少cLEE风险相关的特定ARV或ARV类.

主要方法:

来自RESPOND队列的数据分析,包括2012年1月1日之后开始ARV治疗的个人.
计算每个ARV和暴露时间的每1000人/年cLEE发病率 (IRs).
使用波桑回归来估计发病率比率 (IRR) 并评估ARV和cLEE之间的关联.

主要成果:

在17106人中,共有1932人 (11.3%) 经历了cLEE,总体IR为每1000人年22.0.
没有观察到ARV暴露时间对cLEE发病率的累积影响.
非核酸逆转录酶抑制剂 (NNRTIs) 和二二 fumarate (TDF) 独立地与增加的cLEE风险有关,而达鲁纳维尔 (DRV) 使用与风险降低有关.

结论:

cLEE是常见的,特别是在启动新ARVs的第一年内.
与整合酶链转移抑制剂 (INSTIs) 没有发现短期肝脏安全问题.
非NRTI和TDF与较高的cLEE风险相关,而DRV与较低的风险相关.

关键词:

慢性肝酶升高 (cLEE) 是一种疾病.艾滋病病毒;艾滋病病毒;艾滋病病毒.艾滋病病毒艾滋病病毒艾滋病病毒

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