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Updated: May 7, 2026

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单细胞转录组分析揭示了新生儿骨髓系衍生抑制细胞的异质特征

Meng Yao1, Yingjiao Cao2, Juan He3

  • 1Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease of the Ministry of Education, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

Frontiers in immunology
|June 26, 2024
PubMed
概括

新生儿的骨髓原抑制细胞 (MDSC) 从抗微生物药物成熟到不太有效的形式. 婴儿的这种免疫细胞异质性与他们的发育阶段和健康有关.

关键词:
这就是PMN-MDSC.不同质性的异质性新生儿免疫力 新生儿免疫力过早出生的婴儿早产.一个单细胞RNA测序.

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...