在患有SARS-CoV-2的患者中,血管疾病的发生率增加
Lawrance Lee1, Evan French2, Daniel H Coelho1
1Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Otology & neurotology open
|June 26, 2024
概括
与对照人群相比,COVID-19患者的前体障碍发生率明显高. 这种风险因SARS-CoV-2变种而异,Omicron 23A构成最高风险.
科学领域:
- 耳鼻喉科和神经病学 耳鼻喉科和神经病学
- 传染病和流行病学 传染病和流行病学
- 公共卫生和患者结果.
背景情况:
- 静脉管疾病可以显著影响生活质量.
- 人们越来越认识到SARS-CoV-2 (COVID-19) 感染的神经效应.
- 了解COVID-19和前体功能障碍之间的联系对于患者护理至关重要.
研究的目的:
- 为了确定被诊断为SARS-CoV-2的患者中前置系统疾病的发生率.
- 为了比较COVID-19患者与对照人群的前体疾病风险.
- 为了研究各种SARS-CoV-2变种中前置性疾病发病率的潜在差异.
主要方法:
- 来自国家COVID队列协作 (N3C) 数据库的非识别临床数据的回顾性分析.
- 患者根据SARS-CoV-2感染状况和特定变种流行率 (非类型,α,delta,omicron 21K,omicron 23A) 进行了分类.
- 在COVID-19阳性个体和没有COVID-19感染的对照组之间比较前体障碍发病率.
主要成果:
- 与对照组相比,患有COVID-19的患者患前体障碍的可能性显著更高.
- 在所有分析的SARS-CoV-2变种中,观察到前体疾病的概率比率较高.
- 欧米克朗23A变种显示了最高的相关风险 (OR,8.80;P<0.001),其次是非类型,α,delta和欧米克朗21K变种.
结论:
- 与一般人群相比,COVID-19患者的前体障碍的发生率显著增加.
- 不同的SARS-CoV-2变体之间存在着 vestibular 障碍发病率的显著变化.
- 这些发现强调了对潜在的前体并发症进行患者咨询的必要性,并要求对长期影响进行进一步的研究.
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