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基于中心度的静止状态功能磁共振成像探索腰椎椎间盘的中心机制慢性腰痛患者的腰椎间盘

Jianbing Mei¹, Yong Hu¹

¹Department of Radiology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.

Frontiers in neurology

|June 26, 2024

概括

这项研究揭示了慢性下背痛 (LDHCP) 患者的大脑连接的改变. 特定的大脑区域,如小脑和回,显示出显著的变化,可能有助于理解和诊断LDHCP.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
放射学放射学是一门学科.

背景情况:

慢性腰部疼痛 (LDHCP) 显著影响生活质量.
了解LDHCP的核心机制对于有效治疗至关重要.
休息状态功能磁共振成像 (rs-fMRI) 提供了对大脑功能的洞察.

研究的目的:

通过rs-fMRI和Degree Centrality (DC) 分析来研究LDHCP的中心机制.
为了确定LDHCP患者和健康对照者 (HCs) 之间大脑功能连接的差异.
探索LDHCP患者的大脑活动和临床症状之间的相关性.

主要方法:

从25名LDHCP患者和22名HC患者获得了rs-fMRI数据.
整个大脑DC值在各组之间进行了比较.
分析了DC值与临床评分 (VAS,ODI,疾病持续时间) 之间的相关性.
用接收器操作特征 (ROC) 曲线分析来评估诊断效果.

主要成果:

在LDHCP患者中,小脑和脑干中DC增加.
在LDHCP患者的左侧中圈和右侧中后圈中观察到DC的减少.
左中旋DC与VAS和ODI得分正相关.
罗克分析表明,左侧中圈的诊断效果很高 (AUC=0.929).

结论:

LDHCP与自发神经活动和功能连接的局部异常有关.
已确定的大脑区域 (小脑,脑干,左中圈,右后中圈) 都与LDHCP的病理生理学有关.
与DC分析的rs-fMRI显示了诊断和理解LDHCP的潜力.

关键词:

慢性下背部疼痛慢性下背部疼痛中心性的程度.功能神经成像功能神经成像腰椎椎间盘的发生静止状态的功能连接.

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