预先存在和新出现的代谢功能障碍增加肝硬化和慢性乙型肝炎中其并发症风险
Shang-Chin Huang1,2,3,4, Tung-Hung Su2,3, Tai-Chung Tseng3,5
1Department of Internal Medicine, National Taiwan University Hospital Bei-Hu Branch, Taipei, Taiwan.
The American journal of gastroenterology
|June 26, 2024
概括
代谢功能障碍 (MD) 在慢性乙型肝炎 (CHB) 患者中显著增加肝硬化和并发症风险. 在CHB中早期发现代谢性并发症对于控制肝病进展至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 病毒学 病毒学
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 患病率在慢性乙型肝炎 (CHB) 患者中正在上升.
- 了解代谢功能障碍 (MD) 对CHB肝病进展的影响至关重要.
研究的目的:
- 调查代谢功能障碍 (MD) 与慢性乙型肝炎 (CHB) 患者肝硬化及其并发症风险之间的关联.
主要方法:
- 一组11502名未经治疗的CHB患者被跟踪了中位数5.3年.
- 代谢功能障碍 (MD) 用MASLD定义中的5个心脏代谢标准来定义.
- 患者被分为MD和非MD组进行风险分析.
主要成果:
- 患有多发性硬化症的患者患有肝硬化 (aHR: 1.82) 和肝硬化并发症 (aHR: 1.30) 的风险显著增加,显示出剂量依赖的关系.
- 新发的糖尿病恶化了肝硬化并发症的风险 (aHR:2.87).
- 肝硬化与肝硬化和并发症风险较低有关,但患有肝硬化的MASLD患者的肝硬化风险仍然高于非MD患者.
结论:
- 同时和新发代谢功能障碍 (MD) 独立地增加肝硬化和并发症的风险,无论肝硬化.
- 针对CHB患者的代谢性并发症进行主动查对于准确的肝病风险分层至关重要.
- 这项研究强调了代谢健康和病毒性肝炎在肝病进展中的关键相互作用.
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