在西班牙儿童中增加了Mycoplasma pneumoniae感染的严重程度
Ana Méndez-Echevarría1,2,3,4,5, Laura Calle-Miguel6, Sheila Miralbés7
1From the Pediatric Infectious and Tropical Diseases Department, La Paz Hospital, Madrid, Spain.
The Pediatric infectious disease journal
|June 26, 2024
概括
自2023年底以来,儿科Mycoplasma pneumoniae感染的显著增加,包括严重的肺炎和儿科重症监护室 (PICU) 的入院病例. 这表明这种常见的儿童呼吸道病原体的临床表现更加严重.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 呼吸系统医学 呼吸系统医学
背景情况:
- 自2023年底以来,亚洲儿童中Mycoplasma pneumoniae感染的发病率和严重程度增加.
- 在欧洲国家观察到的后续趋势,可获得的数据有限.
- 启动了一项全国性研究,以界定正在进行的Mycoplasma pneumoniae疫情.
研究的目的:
- 研究住院儿童中Mycoplasma pneumoniae感染的流行病学和临床特征.
- 为了界定西班牙正在进行的Mycoplasma pneumoniae疫情.
- 评估M. pneumoniae感染的严重程度和临床过程.
主要方法:
- 在西班牙32家医院进行的一项多中心回顾性观察性研究.
- 包括2023年1月至2024年3月因M. pneumoniae感染住院的18岁以下患者.
- 通过阳性聚合酶连锁反应和/或两个血清学试验确认感染.
主要成果:
- 总共有623名儿童被纳入,其中79%的儿童在研究的最后3个月内被诊断出患病.
- 肺炎是最常见的诊断 (87%),有97%的人出现呼吸道症状.
- 14%的病例需要进入儿科重症监护室 (PICU),其中包括神经症状和早产等危险因素.
结论:
- 自2023年11月以来,由于M. pneumoniae感染而引起的住院病例显著增加.
- 到14%的住院儿童需要PICU支持,这表明更严重的临床过程.
- 在接受PICU治疗的儿童中观察到更高的中性粒细胞计数.
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