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相关概念视频

Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

13.2K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
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Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

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Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
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相关实验视频

Updated: Jun 23, 2025

Lensless Fluorescent Microscopy on a Chip
11:23

Lensless Fluorescent Microscopy on a Chip

Published on: August 17, 2011

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光多重检测装置使用无镜头矩阵可定位的微LED阵列.

Victor Moro1, Joan Canals1, Sergio Moreno1

  • 1Electronic and Biomedical Engineering Department, University of Barcelona, 08028 Barcelona, Spain.

Biosensors
|June 26, 2024
PubMed
概括
此摘要是机器生成的。

这项研究引入了一种使用GaN和CMOS芯片进行光分析的新型治疗点分子诊断系统 (PoC-MD). 该微系统提供灵敏的光体检测,使得快速诊断.

关键词:
这是一个CMOS系统.在 GaN GaN 中.护理中心的关心点.这就是SPAD SPAD的意思.光是一种光.终身光的光效应一个微型LED阵列.这是一个微型LED驱动器.一个多重复合并的多重复合并.

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Simultaneous Multicolor Imaging of Biological Structures with Fluorescence Photoactivation Localization Microscopy

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相关实验视频

Last Updated: Jun 23, 2025

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Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers
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科学领域:

  • 微型和纳米技术 微型和纳米技术
  • 生物医学工程 生物医学工程
  • 光子学 是一个光子学.

背景情况:

  • 传统的分子诊断仪器通常依赖于重的激光器和光学组件.
  • 需要小型化,集成的系统,用于关心点的分子诊断.
  • 基于光的测量对于检测生物分子至关重要,但需要复杂的设备.

研究的目的:

  • 开发和演示一种用于分子诊断 (PoC-MD) 的新型护理点系统.
  • 将化 (GaN) 和互补金属氧化物半导体 (CMOS) 技术集成到用于光测量的微系统中.
  • 为了能够在护理点分析光强度和寿命.

主要方法:

  • 混合微结构的制造,将32x32可定位的GaN微LED阵列与16x16 SPAD CMOS阵列相结合.
  • 面对面放置GaN微LED和CMOS单光子雪崩二极管 (SPAD) 进行高效的光检测.
  • 在为GaN微型LED阵列定制的CMOS芯片上开发集成驱动程序.

主要成果:

  • 开发的PoC-MD系统可以在32x32点上进行光测量.
  • 在长寿命 (>10 ns) 光体中达到大约1/4μM的检测极限.
  • 使用QdotTM 605和Amino PEG QdotTM 705进行的概念验证测量,包括同时检测.

结论:

  • 混合GaN-CMOS微系统成功地取代了用于光测量的传统体积较大的仪器仪表.
  • PoC-MD系统适用于对特定光体的敏感检测.
  • 这项技术有望推进带有增强灵敏度和可移植性的关照点分子诊断.