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光多重检测装置使用无镜头矩阵可定位的微LED阵列

Victor Moro¹, Joan Canals¹, Sergio Moreno¹

¹Electronic and Biomedical Engineering Department, University of Barcelona, 08028 Barcelona, Spain.

|June 26, 2024

概括

这项研究引入了一种使用GaN和CMOS芯片进行光分析的新型治疗点分子诊断系统 (PoC-MD). 该微系统提供灵敏的光体检测,使得快速诊断.

科学领域:

微型和纳米技术微型和纳米技术
生物医学工程生物医学工程
光子学是一个光子学.

背景情况:

传统的分子诊断仪器通常依赖于重的激光器和光学组件.
需要小型化,集成的系统,用于关心点的分子诊断.
基于光的测量对于检测生物分子至关重要,但需要复杂的设备.

研究的目的:

开发和演示一种用于分子诊断 (PoC-MD) 的新型护理点系统.
将化 (GaN) 和互补金属氧化物半导体 (CMOS) 技术集成到用于光测量的微系统中.
为了能够在护理点分析光强度和寿命.

主要方法:

混合微结构的制造,将32x32可定位的GaN微LED阵列与16x16 SPAD CMOS阵列相结合.
面对面放置GaN微LED和CMOS单光子雪崩二极管 (SPAD) 进行高效的光检测.
在为GaN微型LED阵列定制的CMOS芯片上开发集成驱动程序.

主要成果:

开发的PoC-MD系统可以在32x32点上进行光测量.
在长寿命 (>10 ns) 光体中达到大约1/4μM的检测极限.
使用QdotTM 605和Amino PEG QdotTM 705进行的概念验证测量,包括同时检测.

结论:

混合GaN-CMOS微系统成功地取代了用于光测量的传统体积较大的仪器仪表.
PoC-MD系统适用于对特定光体的敏感检测.
这项技术有望推进带有增强灵敏度和可移植性的关照点分子诊断.

关键词:

这是一个CMOS系统.在 GaN GaN 中.护理中心的关心点.这就是SPAD SPAD的意思.光是一种光.终身光的光效应一个微型LED阵列.这是一个微型LED驱动器.一个多重复合并的多重复合并.

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