富可桑丁及其代谢物富可桑丁醇的抗氧化和神经保护作用:一个比较的体外研究
Letizia Pruccoli1, Martina Balducci1, Barbara Pagliarani1
1Department for Life Quality Studies, University of Bologna, 47921 Rimini, Italy.
Current issues in molecular biology
|June 26, 2024
概括
富可桑丁及其代谢物富可桑丁醇对阿尔茨海默氏症和帕金森病模型表现出抗氧化和神经保护作用. 富可森丁醇表现出类似或更高的活性,这表明它对富可森丁的健康益处有所贡献.
科学领域:
- 海洋天然产品 海洋天然产品
- 神经科学是一个神经科学.
- 生物化学 生物化学
背景情况:
- 富可丁是一种海洋类胡卜素,具有健康益处.
- 富可桑丁被代谢成富可桑丁醇.
- 福可桑丁醇的神经保护作用在很大程度上是未知的.
研究的目的:
- 为了比较富可桑丁和富可桑丁醇的抗氧化和神经保护作用.
- 在阿尔茨海默氏症和帕金森病模型中研究它们的作用机制.
- 探索福可桑丁醇作为促进福可桑丁神经保护性能的潜在作用.
主要方法:
- 在实验室模型中使用神经元SH-SY5Y细胞.
- 对抗ABTS基和三甲基氧化物诱导的氧化应激的抗氧化活性的评估.
- 评估谷氨 (GSH) 水平和Nrf2/Keap1/ARE通路的激活.
- 对β-粉样蛋白寡合体 (OAβ) 和6-氧多巴胺 (6-OHDA) 的神经保护测定.
主要成果:
- 富可桑丁和富可桑丁醇都到达了神经元细胞质,表现出自由基清除活性.
- 与富可桑丁相比,富可桑丁醇表现出较高的细胞外和较低的细胞抗氧化活性.
- 这两种胡卜素都激活了Nrf2/Keap1/ARE通路,增加了细胞内GSH.
- 富可桑丁醇提供神经保护,防止OAβ和6-OHDA毒性,类似于富可桑丁.
结论:
- 富可桑丁和富可桑丁醇的抗氧化活性主要归因于神经元膜和细胞质中的基因清除.
- 富可森丁醇有助于富可森丁所观察到的神经保护作用.
- 需要进一步研究福可桑丁醇在大脑中的生物可用性,以证实福可桑丁的饮食神经保护潜力.
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