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开源设备用于高灵敏度磁粒子光谱,放松度和歇斯底里循环追踪

E Mattingly¹, A C Barksdale², M Śliwiak³

¹Massachusetts Institute of Technology, Health Sciences and Technology, Cambridge, Massachusetts 02139, USA.

The Review of scientific instruments

|June 26, 2024

概括

研究人员开发了一种开源磁纳米粒子 (MNP) 评估设备,用于磁粒子成像 (MPI) 和其他应用. 这种多功能系统提供光谱,放松计和循环追踪功能,具有高灵敏度和广泛的动态范围.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

磁纳米粒子 (MNP) 有多种应用,包括磁粒子成像 (MPI),向高温和免疫测试.
准确评估MNP对于其有效使用至关重要,特别是在MPI中.
设计MNP评估系统的现有资源有限.

研究的目的:

设计和描述一个开源的,用于评估磁纳米粒子的多功能设备.
为建立MNP评估系统提供综合资源.
为了展示该设备在光谱学,放松计和循环追踪方面的功能.

主要方法:

开发了一个开源设备,集成光谱,放松计和循环跟踪功能.
量化检测灵敏度使用70纳米的稀释序列Synomag-D MNPs.
在不同的驱动场强度 (2-18 mT) 和频率 (23.8 kHz) 下测量了MNP响应.

主要成果:

在光谱模式下在一秒内达到260 pg Fe (SNR=1) 和1.3 ng Fe (SNR=5) 的检测灵敏度.
在没有硬件修改的情况下,表现出60μg至260pgFe的广泛动态范围.
描述了Synomag-D放松时间常数,并比较了不同MNP的磁化反应.

结论:

开发的开源设备为MNP表征提供了一个灵敏和多功能平台.
该系统解决了对MNP评估工具的需求,特别是MPI应用程序.
该设备的性能和广泛的动态范围使其适用于各种MNP研究和开发.

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