在更年期妇女中比较植物药物和雌激素-孕激素药物之间的癌症风险和死亡率:基于人口的队列研究
Tsai-Bei Lin1, Chia-Chi Hsieh2,3, Chun-Hsiang Wang4
1Department of Obstetrics and Gynecology, Bao Hua Tang Traditional Chinese Medicine Clinic, Tainan 701033, Taiwan.
Healthcare (Basel, Switzerland)
|June 26, 2024
概括
与绝经后妇女的激素替代疗法 (HRT) 相比,植物药物显著降低了癌症和死亡风险. 像Bupleurum和Peony这样的特定配方显示出显著的益处,表明植物药物作为HRT更安全的替代品.
科学领域:
- 综合性瘤学是一种综合性瘤学.
- 药物监督 药物监督 药物监督
- 妇女健康 妇女健康
背景情况:
- 绝经后综合征通常用雌激素-孕激素药物 (激素替代疗法或HRT) 治疗.
- 与HRT相关的长期风险,包括癌症和死亡率,需要对替代疗法进行调查.
- 植物药物,植物制药,越来越多地被探索为更年期症状管理.
研究的目的:
- 在绝经后的妇女中,比较植物药物使用者和激素替代疗法 (HRT) 使用者之间总体癌症和全因死亡率的长期风险.
- 确定与降低健康风险相关的特定植物制药配方.
- 评估植物药物的潜力,作为更安全的替代方案,HRT为绝经后症状管理.
主要方法:
- 一个1:2匹配的队列研究利用台湾国家健康保险研究数据库 (NHIRD) 从2000年至2018年.
- 包括12,087名符合条件的患者,比较仅使用植物药品的用户 (n=4029) 与仅使用HRT的用户 (n=8058) 经过≥6个月的洗期后.
- 使用调整的危险比率 (aHR) 和95%的置信区间进行统计分析,以评估癌症和死亡风险.
主要成果:
- 植物药物治疗使用者在使用超过180天后,与HRT使用者相比,整体癌症 (aHR:0.60 [0.40-0.9]) 和全因死亡率 (aHR:0.40 [0.16-0.99]) 的风险显著降低.
- 布普勒乌鲁姆和豆配方与降低整体癌症风险 (aHR:0.57 [0.36-0.92]) 和全因死亡率 (aHR:0.33 [0.11-1.05]) 特别相关.
- 这些发现表明,植物药物使用对长期健康结果的概况有利.
结论:
- 植物药物可能是治疗更年期症状的可行替代方案,可能会降低长期健康风险.
- 特定的植物药物配方,如Bupleurum和Peony配方,显示出有前途的安全性和有效性.
- 建议进行进一步的随机对照试验,以验证这些观察结果,并巩固植物药物在绝经后护理中的作用.
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