抗真菌疗法的当前前景观:特别关注Candida auris
Arumugam Ganeshkumar1,2, Manickam Muthuselvam3, Patricia Michelle Nagai de Lima1
1Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos 12245-000, SP, Brazil.
Journal of fungi (Basel, Switzerland)
|June 26, 2024
概括
黄菌感染是一个日益增长的全球威胁,特别是对弱势群体. 本综述探讨了新兴疗法,如天然产品和类药物,以打击抗真菌耐药性并改善治疗结果.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 黄是一种新兴的真菌病原体,在全球引起严重感染.
- 黄菌的抗真菌耐药性有助于高死亡率和发病率,特别是在老年人和免疫力低下的人群中.
- 由于药物耐药性的发展,现有的治疗策略往往会失败.
研究的目的:
- 为了提供对最近针对Candida auris感染的治疗策略的全面概述.
- 整合有关各种治疗方法的信息,包括传统药物,新型化合物和替代疗法.
- 发现当前研究中的差距,并鼓励进一步的临床研究.
主要方法:
- 对Candida auris治疗策略的现有文献进行系统审查.
- 分析各种治疗方式:抗真菌药物,化学化合物,精油,天然产品,抗真菌,免疫疗法,抗微生物光动力疗法,药物重定位和药物输送系统.
- 专注于最近的发展和有效性的证据.
主要成果:
- 目前正在探索多种治疗途径,合成化学品,天然产品和抗真菌显示出显著的前景.
- 目前正在调查各种方法,包括药物重新定位和新型输送系统.
- 审查强调了除了传统的抗真菌药物之外的各种策略的潜力.
结论:
- 虽然许多治疗策略对Candida auris有前途,但临床证据对许多患者仍然有限.
- 进一步的体内研究和临床试验对于验证这些新兴治疗方法的有效性和安全性至关重要.
- 本次审查强调了需要继续进行研究,以应对Candida auris感染和抗真菌耐药性的挑战.
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