Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomas.

The Journal of experimental medicine·2026
Same author

Global proteomic analysis of <i>Cryptococcus neoformans</i> clinical strains reveals significant differences between latent and lethal infection.

mSystems·2025
Same author

Insights from Mass Spectrometry-Based Proteomics on <i>Cryptococcus neoformans</i>.

Journal of fungi (Basel, Switzerland)·2025
Same author

An Optimized In-House Protocol for <i>Cryptococcus neoformans</i> DNA Extraction from Whole Blood: "Comparison of Lysis Buffer and Ox-Bile Methods".

Journal of fungi (Basel, Switzerland)·2025
Same author

Global proteomic analysis of <i>Cryptococcus neoformans</i> clinical strains reveals significant differences between latent and lethal infection.

bioRxiv : the preprint server for biology·2025
Same author

Erratum for Jackson et al., "Virulence-associated variants in <i>Cryptococcus neformans</i> sequence type 93 are less likely to be associated with population structure compared to independent rare mutations".

Microbiology spectrum·2025

相关实验视频

Updated: Jun 23, 2025

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

7.3K

在Cryptococcus neoformans中的同系鼠标模型研究研究

Minna Ding1, Kirsten Nielsen1

  • 1Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA.

Journal of fungi (Basel, Switzerland)
|June 26, 2024
PubMed
概括

鼠标模型对于研究像Cryptococcus这样的真菌感染至关重要. 本文重点介绍了Cryptococcus neoformans研究中使用的常见的内生小鼠菌株,强调它们对疾病结果的影响.

科学领域:

  • 菌类学 菌类学是指菌类学.
  • 免疫学 免疫学 免疫学
  • 传染性疾病 传染性疾病

背景情况:

  • 动物模型对于理解人类疾病至关重要,包括由真菌病原体引起的疾病.
  • 加密球菌物种复合体是一个重要的人类真菌病原体,已经开发了各种小鼠模型来研究其病变.
  • 不同小鼠背景之间的遗传变异可以显著影响宿主免疫反应和感染模型中的疾病进展.

研究的目的:

  • 在Cryptococcus neoformans感染模型的背景下,审查和讨论最常用的近亲生鼠背景.
  • 突出这些小鼠模型中的遗传差异如何影响真菌病原体和宿主病原体相互作用的研究.
  • 为研究人员选择合适的小鼠模型用于Cryptococcus neoformans研究提供资源.

主要方法:

  • 对已发表的研究的文献综述,这些研究使用了针对Cryptococcus neoformans感染的小鼠模型.
  • 分析了使用不同杂交小鼠菌株来研究真菌病原学的研究.
  • 综合有关特定小鼠遗传背景对疾病结果影响的信息.

主要成果:

  • 在Cryptococcus neoformans的研究中经常使用几种同系鼠标菌株.
  • 这些不同的遗传背景表现出不同的宿主对感染的反应,影响疾病的严重程度和呈现.
关键词:
这是Cryptococcus neoformans的新型菌.加密球菌免疫复合炎症综合征这是一种加密球菌脑膜炎.损害应对框架的框架的真菌是一种真菌.宿主免疫反应 宿主免疫反应主体病原体相互作用人类真菌病原体的人类真菌病原体杂交的鼠标模型.潜伏的C. neoformans感染可能存在.

更多相关视频

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging
03:24

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Published on: March 22, 2024

1.4K
Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction
06:19

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

Published on: November 6, 2019

12.8K

相关实验视频

Last Updated: Jun 23, 2025

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

7.3K
Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging
03:24

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Published on: March 22, 2024

1.4K
Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction
06:19

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

Published on: November 6, 2019

12.8K
  • 选择鼠标菌株可以显著影响真菌感染模型中实验结果的解释.

    • 结论:

    • 选择一个合适的杂交小鼠背景对于准确建模人类Cryptococcus neoformans疾病至关重要.
    • 了解不同小鼠菌株的遗传影响对于真菌病原学的可复制和有意义的研究至关重要.
    • 进一步的研究可能会从Cryptococcus neoformans研究中对小鼠菌株特征的标准化报告中受益.