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在Fgf10-缺陷的异卵性老鼠中,哈德利亚腺发育和退化

Shiori Ikeda¹, Keita Sato², Hirofumi Fujita²

¹Department of Cytology and Histology, Medical School, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.

Journal of developmental biology

|June 26, 2024

概括

在小鼠中,纤维细胞生长因子10 (Fgf10) 缺陷导致哈德尔腺 (HG) 发育延迟或缺陷,导致眼睛异常. 在新生儿期早期观察到HG的退化和缩.

科学领域:

发展生物学发展生物学
眼科医生眼科眼科
遗传学是一个遗传学.

背景情况:

鼠标的哈德里亚腺 (HG) 保护眼睛表面,并在眼开放中发挥作用.
受到干扰的HG形成会导致异眼 (裂眼现象型).
之前的研究将Fgf10功能丧失与由于HG缩导致的裂眼联系起来,但时间和机制尚不清楚.

研究的目的:

在Fgf10异合体功能丧失小鼠中调查哈德里腺退化的时间和特征.
阐明Fgf10哈普洛缺陷对HG形成的发育影响.

主要方法:

在胚胎 (E13.5-E19) 和产后 (P0.5-P18) 阶段,以及在老年小鼠 (74周) 中,在Fgf10小鼠中对哈德尔腺体的组织学观察.
对HG标记表达的评估.
在现场杂交以检测Fgf10表达模式.

主要成果:

超过一半的Fgf10小鼠表现出显著退化的HGs,经常单方面,由P10.
退化的HG组织显示出黑色化和由结缔组织替换.
组织学和标记表达显示,在相似比例的Fgf10胚胎中,HG发育延迟或中断.

结论:

Fgf10的哈普洛缺陷导致哈德尔腺发育延迟或缺陷.
在Fgf10小鼠中,HG退化和缩发生在新生儿期的早期.
这种发育缺陷可能会导致由于HG缩而导致单边的眼.

关键词:

在Fgf10中,Fgf10是什么意思?哈德里亚的腺体哈德里亚的腺体简单地说,这是一个简单的缺陷.这里是鼠标鼠标鼠标鼠标鼠标鼠标.

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