基于树脂的新型抗菌根表面涂料材料,用于打击牙变
Nader Almutairi1,2, Abdullah Alhussein3, Mohammad Alenizy1,4
1PhD Program in Dental Biomedical Sciences, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
Journal of functional biomaterials
|June 26, 2024
概括
一种含有二甲基胺六甲基甲基酸盐 (DMAHDM) 的新型抗菌涂层有效地对抗根. 这种牙材料显示强大的抗菌作用,对抗低毒性的菌细菌,保护天然牙.
科学领域:
- 生物材料科学 生物材料科学
- 牙科研究 牙科研究
- 微生物学 微生物学
背景情况:
- 根腔是一种重大的全球口腔健康挑战,尤其对老年人来说.
- 暴露的根表面易受菌的侵蚀,因此需要采取保护策略.
- 目前的治疗方法往往侧重于管理已建立的衰变,而不是预防.
研究的目的:
- 开发和评估一种新型的抗菌涂层,用于预防根.
- 为了评估在牙科树脂配方中的二甲基氨基二甲基酸盐 (DMAHDM) 的疗效.
- 确定开发的涂层的物理,机械,抗菌和细胞毒性质.
主要方法:
- 合成DMAHDM并将其纳入尿二甲酸盐 (UDMA) 和TEG-DVBE树脂,并使用玻璃填充剂.
- 测试了各种DMAHDM度对树脂性能的影响.
- 分析了对S.的抗菌疗效. 突变生物膜和对人类牙纤维细胞 (HGFs) 的评估细胞毒性.
主要成果:
- 在5%的DMAHDM度下,S.降低了8日志. 生物膜中的突变种殖民地形成单位 (CFU).
- 证明生物膜代谢活动和乳酸生产减少了90%.
- 该涂层对HGFs具有较低的细胞毒性,同时保持了理想的物理和机械性能.
结论:
- 基于DMAHDM的抗菌涂层显示出预防根的巨大潜力.
- 它强大的抗菌活性,低毒性和有利的材料特性使其适合保护暴露的根表面.
- 这种新型材料可以在牙科手术和患有牙衰退的老年人中发挥有益作用.
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