主要不良心血管事件与周围动脉疾病负担之间的关联
Oskari Niiranen1, Juha Virtanen2, Ville Rantasalo1
1Department of Surgery, University of Turku, 20520 Turku, Finland.
在外周动脉疾病 (PAD) 患者中,严重的小腿动脉样硬化显著增加了包括心力衰竭在内的主要心血管不良事件 (MACE) 的风险. 风险随着小腿骨血管动脉样硬化严重程度的增加而升级.
科学领域:
- 心血管医学 心血管医学
- 血管外科 血管外科
- 诊断成像 诊断成像 诊断成像
背景情况:
- 周围动脉疾病 (PAD) 影响下肢的血液循环.
- 动脉样硬化是PAD的主要原因.
- 了解动脉样硬化负担与心血管事件之间的联系至关重要.
研究的目的:
- 调查下肢动脉硬化和主要不良心血管事件 (MACEs) 的细分负担之间的关系.
- 为了确定动脉样硬化的位置和严重程度是否会影响MACE风险.
主要方法:
- 对经过数字减去血管学 (DSA) 的有症状的PAD患者的回顾性分析.
- 动脉样硬化负担的分类为大动脉-阴茎,股骨或骨段.
- MACE被定义为脑血管事件,心力衰竭 (HF) 或心肌梗塞.
主要成果:
- 骨血管动脉样硬化与HF (OR 3.9) 和整体MACE (OR 2.3) 的风险增加密切相关.
- 肌动脉样硬化的严重程度增加直接提高了HF和MACE的风险.
- 雌性多动脉样硬化也增加了HF (OR 2.3) 和MACE风险 (OR 1.9),其程度仅影响MACE风险.
结论:
- 在PAD患者中,严重的小腿动脉样硬化是MACEs的显著预测因子.
- MACE 的风险与骨血管动脉样硬化症的严重程度成比例增加.
- 虽然甲状腺样硬化没有显示MACE相关性,但股骨关节的参与增加了MACE风险.
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