一个多功能蛋白质预涂层的金属有机框架,用于深层组织透的有针对性的输送
Jun Yong Oh1, Min-Seok Seu1, Ayan Kumar Barui1
1Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea. jhryu@unist.ac.kr.
Nanoscale
|June 26, 2024
概括
我们设计了涂有蛋白质的多功能纳米尺寸金属有机框架 (MOF),以克服瘤微环境 (TME). 这种向的药物递送系统增强了癌细胞的透率和治疗效率.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 癌症治疗方法 癌症治疗方法
背景情况:
- 使用金属有机框架 (MOFs) 的向药物递送面临挑战,因为瘤微环境 (TME) 阻碍了颗粒内部化.
- 对TME的有效导航对于有效的基于MOF的癌症治疗至关重要.
研究的目的:
- 开发一种基于MOF的新型向药物输送系统,能够克服TME障碍.
- 在固体瘤中增强MOF粒子透和细胞吸收.
主要方法:
- 纳米大小的MOF-808颗粒被用谷氨S转移酶 (GST) - 亲体 (Afb) 融合蛋白和原酶酶表面功能化.
- GST-Afb促进了特定的瘤细胞向 (HER2或EGFR),而原酶降解了细胞外基质 (ECM).
- 修改后的MOFs (Col-Afb-M808) 在3D癌症模型和体内瘤模型中进行了评估.
主要成果:
- Col-Afb-M808显示减少非特异性蛋白质吸附和通过ECM增强透.
- 该系统实现了特定的瘤细胞向,并在球形模型中改善了细胞内部化.
- 在体内研究表明,在4T1瘤携带的小鼠中,有效的深层组织透和显著的瘤抑制.
结论:
- 多功能蛋白质涂层MOF系统有效地导航TME,改善向药物输送.
- 这种方法为设计用于癌症治疗的先进纳米尺寸MOF药物递送系统提供了一个有希望的策略.
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