老年妇女的糖尿病和高血压:严重程度和无法控制炎症之间的相互作用
Paulo Henrique B Lima1, Caroline V Goncalves1, Israel S Ribeiro2
1Universidade Federal da Bahia, Instituto Multidisciplinar em Saúde, Campus Anísio Teixeira, Rua Rio de Contas, 58, Bloco 17, Lote 58, Candeias, 45029-094 Vitória da Conquista, BA, Brazil.
Anais da Academia Brasileira de Ciencias
|June 26, 2024
概括
这项研究显示,患有高血压和糖尿病的老年妇女随着疾病严重程度的增加,在炎症标志物和人类学上表现出显著的变化. 非常高风险组表现出炎症反应的丧失,表明健康状况危急.
科学领域:
- 老年学是一门学科.
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 老年妇女容易患上慢性疾病,如糖尿病 (DM) 和全身性动脉高血压 (SAH).
- 了解各种健康参数的相互作用对于评估这种人口中的疾病严重程度至关重要.
研究的目的:
- 研究人体测量,生化和炎症标志物与高血压和糖尿病的老年妇女的疾病严重程度之间的关联.
- 为脆弱人群提供这些相互作用的扩展视图.
主要方法:
- 评估了126名被诊断患有高血压和糖尿病的老年妇女.
- 将参与者分为低,中等,高和非常高的疾病严重程度组.
- 通过生物阻抗分析收集人体测量数据,并分析血液样本以检测生化和炎症标志物.
主要成果:
- 增加的腰围,腰与身高的比率和血压与更高的疾病严重程度相关.
- 大多数生物化学标志物都随着严重程度的增加而上升,除了HDL胆固醇.
- 非常高风险组显示IL-1β,IFN-γ,TNF-α升高,IL-10降低,IL-10比率改变,表明炎症反应减弱.
结论:
- 患有高血压和糖尿病的老年妇女的疾病严重程度与人体测量,生化和炎症概况的显著变化有关.
- 非常高风险组显示出受损的炎症反应,突出显示了危急状态.
- 这项研究提供了对这些相互关联的因素的全面分析,这些因素在老年女性中存在着同时存在的高血压和糖尿病.
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