使用常规血液检测和机器学习来确定COVID-19疾病严重程度的预后标记
Tayná E Lima1, Matheus V F Ferraz1,2, Carlos A A Brito3
1Fundação Oswaldo Cruz, Instituto Aggeu Magalhães, Departamento de Virologia, Av. Professor Moraes Rego, s/n, Cidade Universitária, 50740-465 Recife, PE, Brazil.
Anais da Academia Brasileira de Ciencias
|June 26, 2024
概括
识别COVID-19严重性风险因素至关重要. 机器学习从例行血液检查中确定了五个关键生物标志物,以准确预测严重疾病,帮助临床决策.
科学领域:
- * 医学信息学 医学信息学
- * 临床病理学 临床病理学
- * 传染病 传染病
背景情况:
- *确定COVID-19严重性风险因素对于患者护理和资源分配至关重要.
- *目前的疾病严重程度分类依赖于非标准化的临床参数和血液测试,导致数据冲突.
- *机器学习 (ML) 为开发标准化和准确的预测模型提供了一个潜在的解决方案.
研究的目的:
- * 构建和验证用于预测COVID-19疾病严重程度的机器学习 (ML) 模型.
- * 确定与严重的COVID-19结果相关的关键实验室生物标志物.
主要方法:
- * 通过使用电子医疗记录和来自巴西72名COVID-19患者的日常血液检测结果,开发了一种机器学习模型.
- *患者使用RT-PCR和/或ELISA进行诊断,疾病严重程度各不相同.
- * 模型的预测准确性是使用曲线下的接收器操作特征面积 (ROC-AUC) 来评估的.
主要成果:
- * 五种实验室生物标志物的组合准确预测了严重的COVID-19疾病,ROC-AUC为0.80±0.13.
- *已确定的生物标志物包括前激素活性,费里丁,血清铁,激活的部分血栓形成时间 (APTT) 和单细胞.
- *ML模型在预测疾病严重程度方面显示出显著的潜力.
结论:
- *开发的ML模型有效地使用现有的实验室数据预测COVID-19的严重程度.
- *已识别的生物标志物为严重的COVID-19的病理生理学提供了宝贵的见解.
- * 这个工具可以帮助合理化临床决策和优化患者护理策略.
相关概念视频
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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
136
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
76