穿皮利切除术中使用的入口直径对功能的影响:一项前性随机研究
Deniz Noyan Özlü1, Mithat Ekşi2, Selçuk Şahin2
1Department of Urology, University of Health Sciences Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey. noyanozlu@hotmail.com.
Urolithiasis
|June 26, 2024
概括
接入的直径不会影响脏功能,经过皮肤透神经利息切除术 (PNL). 然而,较大的石头体积独立地预测PNL后功能丧失.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 手术创新 在外科创新.
背景情况:
- 透皮石切除术 (PNL) 是结石去除的关键手术.
- 在PNL中选择接入口直径可能会影响术后功能.
- 了解影响PNL后功能因素对于患者的治疗结果至关重要.
研究的目的:
- 评估PNL中不同接入直径 (22 Fr vs. 28 Fr) 对后续功能的影响.
- 为了确定PNL后功能受损的预测因素.
- 评估PNL后的相对功能 (RRF) 和膜过率 (GFR) 的变化.
主要方法:
- 对88名接受PNL的患者进行前性随机研究,分为22 Fr和28 Fr接入组.
- 功能评估使用技术-99m二聚糖酸光学对RRF和乙二胺五酸光学对GFR.
- 损伤分子-1 (KIM-1) 水平在手术前和手术后测量;收集石块体积和人口统计数据.
主要成果:
- 在22 Fr和28 Fr组之间,RRF,GFR或KIM-1/肌素水平没有统计学上显著的差异.
- 总体而言,6.8%的患者经历了显著的RRF恶化,每个组有3名患者.
- 多变量分析确定石块体积是功能丧失的唯一独立预测因素 (p=0.002).
结论:
- 在PNL中使用的接入口直径不会显著影响功能.
- 石块体积是PNL后功能障碍的重要独立预测因素.
- 进一步的研究可能会探索减轻大石头负担患者功能损失的策略.
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
81
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
81
01:11Renal Failure: Dose Adjustments
79
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
79