肝炎E的积极监测:在中国东部的一个城市进行了为期10年的流行病学分析
Xingcheng Huang1,2, Xiaoxiang Zheng3, Lin Chen3
1State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, People's Republic of China.
Emerging microbes & infections
|June 26, 2024
概括
在过去10年中,中国的E型肝炎 (HE) 发病率下降,男性和老年人的发病率更高. 积极监测显示,HE的发病率高于国家报告,凸显了针对风险群体进行有针对性的预防的必要性.
科学领域:
- *肝病学和病毒学
- * 公共卫生和流行病学
- * 传染病监测 传染病监测
背景情况:
- * 肝炎E病毒 (HEV) 是急性肝炎的重要原因,但报告不足.
- *现有的国家监测系统可能低估了HEV感染的真正负担.
- *了解高等教育流行病学对于有效的公共卫生干预至关重要.
研究的目的:
- * 在中国东台市开展10年E型肝炎流行病学积极监测.
- * 为了比较主动监测结果与国家可通报疾病报告系统 (NNDRS).
- * 为了确定患有肝炎E感染的高风险人群.
主要方法:
- * 2007年11月至2017年10月期间,社区主动监测涉及355,673名居民.
- *分析了肝炎症状和ALT水平升高的患者的血清样本.
- *对HEV抗体,HEVRNA和乙型肝炎表面抗原 (HBsAg) 的检测;基因型鉴定.
主要成果:
- * 年平均年龄标准化HE发病率为每10万人中17.50,超过NNDRS率 (每10万人中10.26).
- *男性 (20.95/100,000) 和50-69岁 (37.47/100,000) 个体的发病率较高.
- *HEV基因型4占主导地位;HEV和HBV联合感染的发生率为每10万人中有4.99.
结论:
- * 积极监测提供了比被动报告系统更准确的HE发病率图片.
- *在过去十年中,高血压发病率呈下降趋势,但仍然是一个公共卫生问题.
- *需要针对男性,老年人和同时感染HBV的个人制定有针对性的预防策略.
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