固体瘤同步大脑转移的风险因素,预后因素和名ograms:一个基于人口的研究
Leiyuan Liu1,2, Wenqiang Che3,4, Bingdong Xu1,2
1Clinical Neuroscience Institute, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Neurosurgical review
|June 26, 2024
概括
同步大脑转移 (S-BM) 的早期死亡率很高,其中76.4%的患者在一年内死亡. 一个经过验证的诺姆图有助于预测这种风险,有助于S-BM患者的临床决策.
科学领域:
- 在瘤学瘤学.
- 医学统计 医学统计
- 公共卫生 公共卫生
背景情况:
- 有限的研究存在于同步大脑转移 (S-BM) 的短期预后.
- 了解早期死亡风险因素对于管理S-BM患者至关重要.
研究的目的:
- 使用SEER数据库评估S-BM患者的早期死亡率.
- 为了确定与S-BM患者的早期死亡率 (≤1年) 相关的风险因素.
- 在S-BM.中开发和验证1年死亡率的预测性名录.
主要方法:
- 来自监测,流行病学和最终结果 (SEER) 数据库的47284名患者的分析.
- 卡普兰-梅尔曲线用于早期死亡率评估.
- 后勤回归用于预后因素识别和名录构造.
- 接收器操作特征 (ROC) 和决策曲线分析 (DCA) 用于模型验证.
主要成果:
- 发现S-BM患者的1年早期死亡率为76.4%.
- 一个经过验证的名录图用显著的预后因素来预测1年死亡率.
- 诺米图表显示出良好的预测能力 (AUC训练:0.764,AUC验证:0.761) 和临床实用性.
结论:
- 同步大脑转移带有相当大的早期死亡风险.
- 开发的诺米克图是预测S-BM患者1年死亡率的宝贵工具.
- 这种工具可以帮助临床医生识别高风险个体并优化治疗策略.
相关概念视频
Cancer Survival Analysis
342
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
342
Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K


