阿尔茨海默病中的精神病和疾病相关生物标志物的升高
Jesus J Gomar1, Jeremy Koppel1,2
1Feinstein Institutes for Medical Research, Manhasset, New York.
JAMA psychiatry
|June 26, 2024
概括
在阿尔茨海默氏症 (AD) 中出现的精神病与升的化陶 (p-tau181) 水平相关. 这表明p-tau181可能作为阿尔茨海默病患者神经精神病症状的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 阿尔茨海默病 (AD) 中的精神病症状与更快的认知和功能衰退有关.
- 了解特定生物标志物与阿尔茨海默病中精神病出现之间的关系对于疾病管理至关重要.
研究的目的:
- 为了检查化 (p-tau181) 和神经纤维光链 (NfL) 水平的纵向变化.
- 研究这些生物标志物与阿尔茨海默氏症患者精神病症状 (妄想,幻觉) 的出现之间的关联.
主要方法:
- 一项使用阿尔茨海默病神经成像计划 (ADNI) 纵向数据的队列研究.
- 分析包括患有轻度认知障碍 (MCI) 和AD的参与者,按精神病状况分类 (在基线时存在或不存在,或发生精神病).
- 在48个月的时间内量化了血p-tau181和NfL水平,同时使用神经精神病学库存 (NPI) 进行神经精神病学评估.
主要成果:
- 与基线精神病患者相比,发生精神病患者的血p-tau181水平增加.
- 在事件和基线精神病组之间观察到p-tau181变化轨迹的显著差异,特别是在氨基酸β阳性个体中.
- 在研究期间的任何时候,高NfL水平与精神病的经历有关.
结论:
- 在AD中精神病的出现与血p-tau181水平的增加有关.
- 血p-tau181显示出作为AD中神经精神疾病表现的生物标志物的潜力.
- 这些发现可能会为患有精神病的阿兹海默症患者的预测策略和治疗反应提供信息.
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