在桥梁诊所治疗奔阿兹匹因戒断
Jordana Laks1, Theresa W Kim, Paul J Christine
1From the Grayken Center for Addiction, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, MA (JL, TWK, JLT); Boston Health Care for the Homeless Program, Boston, MA (JL, MY); Department of Internal Medicine, University of Colorado School of Medicine, Aurora, CO (PJC); Department of General Internal Medicine, Denver Health and Hospital Authority, Denver, CO (PJC); The Dimock Center, Boston, MA (JE); Department of Quality and Patient Safety, Boston Medical Center, Boston, MA (NMF); Department of Emergency Medicine, Boston University School of Medicine, Boston, MA (NMF); New England Medical Group, Hingham, MA (JK); and Ascend Integrative Medicine, Boston, MA (JK).
门诊患者的奔胺缩剂对阿片类药物使用障碍患者来说具有挑战性. 密集的协议显示出希望,但需要进一步细化,以确保安全性和长期结果.
科学领域:
- 成 药物 药物 药物 药物
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 二甲涉及的过量死亡人数正在增加,主要是由于非处方二甲药丸.
- 住院快速收缩往往是管理佐地亚类药物戒断的唯一选择.
- 药物使用障碍桥梁诊所可以支持对高风险患者的门诊治疗.
研究的目的:
- 描述一下门诊患者使用二胺缩剂的实施方案.
- 评估本协议在物质使用障碍桥梁诊所中的短期结果.
- 评估在高风险人群中管理二二类药物戒断的可行性和安全性.
主要方法:
- 开发了一种使用迪亚泽巴姆的4至6周的密集门诊逐渐缩小方案.
- 符合条件的标准包括二甲戒断,缺乏处方医生,以及停止使用二甲的愿望.
- 评估的结果包括逐渐完成,安全事件 (发作,过量服用,死亡) 和二级护理转诊.
主要成果:
- 54名患者启动了60次逐渐缩小;23%完成了该方案.
- 失去随访 (57%) 和推入院治疗 (18%) 是停用缩剂的主要原因.
- 在那些没有完成逐渐缩小的人群中,发生了两次发作和四次涉及阿片类药物的过量服用;没有报告死亡.
结论:
- 密集的门诊班佐地亚平缓和剂对同时出现班佐地亚平和阿片类药物使用障碍的患者来说具有挑战性.
- 需要进一步的研究来优化患者的选择,并平衡安全与可行性.
- 长期的,以患者为中心的结果需要进一步的研究.
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