便中的挥发性有机化合物根据小儿科患者的炎症性肠病亚型,严重程度和治疗反应而有所不同
Salma Belnour1, Rachael Slater2, Kukatharmini Tharmaratnam3
1Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.
United European gastroenterology journal
|June 26, 2024
概括
患有炎症性肠病 (IBD) 的儿童的便挥发性有机化合物 (VOC) 显示出与疾病类型和严重程度相关的明显模式. 尽管接受了治疗,但这些模式仍然存在,这表明儿科IBD患者的肠道失调正在持续.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 生物化学 生化学
背景情况:
- 已知便中的挥发性有机化合物 (VOC) 根据疾病亚型和IBD成年人的活性而有所不同.
- 了解儿童的这些变异对于早期诊断和治疗儿科IBD至关重要.
研究的目的:
- 在新诊断出IBD的儿童中描述便中的VOC模式.
- 为了将这些模式与疾病亚型,严重程度和治疗反应相关联.
主要方法:
- 从三家英国医院招募疑似IBD的儿童.
- 根据年龄,性别和招募地点,将IBD患者与非IBD对照进行匹配.
- 便VOC分析使用气色谱-质谱在呈现时和处理后3个月.
主要成果:
- 在IBD患者和对照人群之间观察到便中VOC丰度的显著差异,在62种VOC中27种显示变化的水平.
- 子,二子,脂肪酸和酒精特别受到影响,克罗恩病 (CD) 和性结肠炎 (UC) 的减少.
- 严重的大肠炎显示,短链,中链和分支链脂肪酸显著减少. 尽管临床情况有所改善,但VOC概况在很大程度上仍然存在,这表明持续的失生症. 特定的VOC如Oct-1-en-3-ol,propan-1-ol和显示出与疾病类型和治疗反应相关的显著变化.
结论:
- 在儿科IBD中便VOC分析揭示了与诊断,疾病活性和程度相关的独特模式.
- 这些发现凸显了VOCs作为儿童IBD生物标志物的潜力.
- 需要进一步的研究来探索VOCs,肠道微生物群之间的关系,以及它们在IBD诊断和监测中的实用性.
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