Cutibacterium acnes污染并没有提高血小板度的炎症性特征
Dilini Kumaran1,2, Sandra Ramirez-Arcos1,2
1Medical Affairs and Innovation, Canadian Blood Services, Ottawa, Ontario, Canada.
Transfusion
|June 26, 2024
概括
在血小板缩剂 (PCs) 中的Cutibacterium acnes污染不会增加储存期间的炎症因素. 这表明C. acnes可能不会增加输血反应的风险,与更繁殖的细菌不同.
科学领域:
- 输血医学 输血医学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 杆菌 (Cutibacterium acnes) 是血小板缩剂 (PCs) 中常见的污染物.
- 虽然通常被认为是无害的,但C. acnes可以导致慢性感染并诱导细胞因子的释放.
- 在PC中增加的促炎因素与非传染性不良反应有关.
研究的目的:
- 调查PC中的C. acnes污染是否会导致储存期间的炎症因素的积累.
- 评估C. acnes增加输血相关炎症反应风险的潜力.
主要方法:
- 四个ABO匹配的buffycoatPC被组合并分为单位.
- 单位被注射盐水 (对照),金黄色葡萄球菌 (阳性对照) 或C. acnes分离物.
- 细菌计数,血小板激活和促炎因素在5天的20-24°C储存时间内被测量.
主要成果:
- 菌的数量保持稳定,而金黄色葡萄球菌的数量显著增多.
- 与对照组相比,在受C. acnes污染的PC中没有发现血小板激活或细胞因子配置的显著差异.
- 金黄色葡萄球菌污染导致sCD40L,血小板激活和IL-8的增加.
结论:
- 当C. acnes污染不扩散时,它不会在储存的PC中促进促炎因子的积累.
- 在这些条件下,C. acnes可能不会增加炎症输血反应的风险.
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