肝脏参与登革热:一个系统的审查
Valentine Campana1,2, Catherine Inizan3, Jean-David Pommier4
1CIC Antilles Guyane, INSERM CIC1424, Fort-de-France, France.
Reviews in medical virology
|June 26, 2024
概括
早期诊断与登革热相关的肝脏干扰至关重要. 这一系统性审查强调了关键的临床和生物特征,强调监测转氨酶和超声波,以有效管理严重的登革热.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 肝脏受影响是登革热不常见但经常被忽视的并发症.
- 准确地描述登革热相关的肝损伤对于有效的临床管理和预后至关重要.
- 早期诊断依赖于了解临床表现,生物标志物和严重登革热的关联.
研究的目的:
- 系统地审查和综合登革热相关的肝脏参与的临床和生物特征.
- 为了确定预后因素,与严重登革热的关联,以及最佳的临床管理策略.
- 为有效的诊断和患者护理提供全面的概述.
主要方法:
- 使用PubMed和Web of Science数据库进行了系统审查.
- 包括原始病例报告,队列和关于登革热相关肝脏参与的横截面研究.
- 该审查已与PROSPERO (CRD42021262657) 进行注册.
主要成果:
- 与登革热相关的肝脏干扰呈现腹痛,肝壮,黄,恶心/吐,超声波显示肝细胞缩.
- 肝酶 (AST,ALT),胆红素,ALP,GGT,INR,肌素和CK的升高,与白蛋白的降低,是普遍存在的.
- 与严重登革热,心血管/血液学并发症有很强的关联,在男性和老年人中更常见,与DENV-2和二次感染有关.
结论:
- 过氨酶的早期监测,临床评估和超声波是诊断登革热相关肝脏参与的关键.
- 这种方法有助于早期识别和管理严重登革热病例.
- 通常采用保守的管理方法,早期使用青被认为是危险因素.
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