相关实验视频

Updated: Jun 23, 2025

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

10.0K

在风险算法中添加单核酸多形态能否改善心血管疾病风险预测和类风湿关节炎? 临床风险评分的内部和外部验证

Rabia Agca1, Calin D Popa2, Martijn W Heymans3

  • 1Amsterdam Rheumatology and Immunology Center, Amsterdam, the Netherlands.

Arthritis care & research
|June 26, 2024
PubMed
概括

单核酸多态 (SNP) 显示与风湿性关节炎 (RA) 患者的心血管疾病 (CVD) 有关. 虽然增加SNP略有改善了风险预测模型,但它们的临床相关性需要在更大的研究中进一步调查.

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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