在艾滋病毒感染的老年人中,从糖尿病前期发展为糖尿病的危险因素
Mary Clare Masters1, Katherine Tassiopoulos2, Yajing Bao2
1Northwestern University, Chicago, Illinois.
AIDS (London, England)
|June 26, 2024
概括
从糖尿病前期到糖尿病的进展在接受现代抗逆转录病毒治疗的HIV患者中很常见. 较高的BMI,腰围和较低的CD4计数增加了这种人群中的糖尿病风险.
科学领域:
- 传染性疾病 传染性疾病
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 糖尿病前期和糖尿病 (DM) 对于接受现代抗逆转录病毒疗法 (ART) 的艾滋病毒感染者 (PWH) 来说是一个重大问题.
- 了解糖尿病前期的PWH中DM进展的风险因素对于优化长期健康结果至关重要.
研究的目的:
- 在接受现代抗逆转录病毒疗法 (ART) 的艾滋病毒感染者 (PWH) 中,描述从糖尿病前期发展为糖尿病 (DM) 的风险因素.
主要方法:
- 一项观察性队列研究 (ACTG A5322,HAILO) 包括40岁以上的PWH,他们通过ACTG试验启动了ART.
- 考克斯比例危险回归模型被用于确定糖尿病前期参与者DM发展的风险因素.
主要成果:
- 在被诊断为糖尿病前期的753名PWH中,有167人 (22%) 进展为糖尿病前期.
- 在糖尿病前期诊断时,较高的BMI,较低的CD4计数 (≤200细胞/毫米3),高甘油三血和腰围增加与患DM的风险更高有关.
结论:
- 在现代ART的病毒抑制PWH中,糖尿病前期和DM进展率仍然很高.
- 传统的DM风险因素,如BMI和腰围,以及较低的CD4计数,与糖尿病前期的PWH患者的DM风险增加有关.
- 需要进一步的研究和干预措施来预防DM,并改善PWH的长期结果.
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