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Updated: Jun 23, 2025

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Corticospinal Excitability Modulation During Action Observation
Published on: December 31, 2013
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感觉和期望是嵌入在老鼠运动皮质活动中的
Brooke E Holey1, David M Schneider2
1Center for Neural Science, New York University, New York, NY 10003, USA; Neuroscience Institute, NYU Medical Center, New York, NY 10016, USA.
Cell reports
|June 26, 2024
概括
二级运动皮层 (M2) 中的神经元处理感官信息,并由期望塑造. 这个运动皮层区域动态地整合了自我生成的声音,并预测了它们在行为过程中的声学后果.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 感官处理 感官处理
背景情况:
- 运动皮层传统上专注于运动输出.
- 运动皮层在行为过程中也与感官系统相互作用.
- 二级运动皮层 (M2) 在整合感官反中的作用尚未完全理解.
研究的目的:
- 为了调查小鼠的二级运动皮质 (M2) 神经元是否编码感觉.
- 为了确定M2活动是否受到行为期间预期的影响.
- 阐明M2中感觉-运动集成背后的电路机制.
主要方法:
- 在小鼠中闭环行为范式.
- 大规模的电生理学记录.
- 投影模式特定的神经记录和电路扰动.
主要成果:
- 当运动产生意想不到的听觉反时,M2神经元表现出显著的声音唤起活动.
- 在M2中,听觉反应部分是从听觉皮层继承的,并且相互连接.
- M2选择性地关闭对可预测的自我生成声音的响应,展示基于预期的调制.
- 在M2中的人口动态反映了传感输入和预期信号的整合.
结论:
- 鼠标的二级运动皮层 (M2) 神经元编码感官信息,并由期望调节.
- 在活动行为过程中,M2在感官运动信息的动态,相互交换中起着至关重要的作用.
- 这些发现表明,运动皮质活动与感官和预测信号嵌入在一起.
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