局部药物在预防口腔粘膜炎中的有效性:系统性审查和网络元分析
Martina Coppini1,2, Vito Carlo Alberto Caponio3, Rodolfo Mauceri1,4
1Department of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, Palermo, Italy.
Oral diseases
|June 26, 2024
概括
在癌症患者中,局部用苏克拉夫酸盐有效预防口腔粘膜炎 (OM). 这种细胞保护剂提供了一种安全,低成本,易于管理的选择,可以改善癌症治疗结果和患者的生活质量.
科学领域:
- 在瘤学瘤学.
- 口腔医学是指口腔医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 口腔粘膜炎 (OM) 是癌症治疗的常见和衰弱的副作用.
- 有效的OM预防对于维持癌症治疗疗效和患者生活质量至关重要.
- 现有的预防策略在临床试验中显示不确定的结果.
研究的目的:
- 系统地审查和分析局部药物的有效性,以预防癌症患者的口腔粘膜炎.
- 使用PICO框架将局部药物与标准治疗或安慰剂进行比较.
- 为了确定对OM预防最有效的干预措施.
主要方法:
- 在PubMed,Scopus,Web of Science和Cochrane数据库中进行系统的文献搜索.
- 包括30项随机临床试验,涉及2564名癌症患者.
- 网络元分析以评估偏见的风险并比较干预的有效性.
主要成果:
- 自然产品是最常被研究的干预措施.
- 局部使用的苏克拉夫酸盐表现出对口腔粘膜炎最强的预防作用 (OR = 0.04,95%CI). = 0.01-0.25,p = 0.001) 的情况.
- 分析了2564名患者,1284名患者在试验组,1280名患者在对照组.
结论:
- 局部使用的苏克拉酸盐是预防癌症治疗期间口腔粘膜炎的高效药物.
- 糖酸盐的细胞保护性质,可负担性,易用性和安全性使其成为一个有前途的选择.
- 糖酸盐可以成为管理癌症治疗副作用的有价值的辅助剂.
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